caa a22 4500 477127355 CHVBK 20180405111653.0 cr unu---uuuuu 170330e19970401xx s 000 0 eng 10.1023/A:1012018709641 doi (NATIONALLICENCE)springer-10.1023/A:1012018709641 Capillary Electrophoresis in Pharmaceutical Analysis [Elektronische Daten] [Lisa Holland, Nik Chetwyn, Melissa Perkins, Susan Lunte] Capillary electrophoresis (CE) is a separation technique particularly suited to the analysis of pharmaceutical compounds. This review offers a detailed discussion of the four common modes of detection coupled to CE—UV absorption, fluorescence, electrochemical, and mass spectrometry—and gives examples of the use of these methods in pharmaceutical analyses. Sample preparation and pretreatment techniques used for CE separations are described, as well as methods of preconcentration including hydrophobic retention, affinity concentration, sample stacking, and isotachophoresis. The use of affinity CE, chiral CE, and capillary gel electrophoresis for analysis of pharmaceuticals is covered in detail, and recent advances in capillary electrochromatography and CE on a chip are also discussed. Plenum Publishing Corporation, 1997 capillary electrophoresis nationallicence pharmaceutical analysis nationallicence detection nationallicence metabolites nationallicence pretreatment nationallicence preconcentration nationallicence chiral separations nationallicence Holland Lisa Department of Pharmaceutical Chemistry and, Center for Bioanalytical Research The University of Kansas, 2095 Constant Avenue, 66047, Lawrence, Kansas aut Chetwyn Nik Department of Pharmaceutical Chemistry and, Center for Bioanalytical Research The University of Kansas, 2095 Constant Avenue, 66047, Lawrence, Kansas aut Perkins Melissa Department of Pharmaceutical Chemistry and, Center for Bioanalytical Research The University of Kansas, 2095 Constant Avenue, 66047, Lawrence, Kansas aut Lunte Susan Department of Pharmaceutical Chemistry and, Center for Bioanalytical Research The University of Kansas, 2095 Constant Avenue, 66047, Lawrence, Kansas aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/4(1997-04-01), 372-387 0724-8741 14:4<372 1997 14 11095 https://doi.org/10.1023/A:1012018709641 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012018709641 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holland Lisa Department of Pharmaceutical Chemistry and, Center for Bioanalytical Research The University of Kansas, 2095 Constant Avenue, 66047, Lawrence, Kansas aut NATIONALLICENCE 700 1- Chetwyn Nik Department of Pharmaceutical Chemistry and, Center for Bioanalytical Research The University of Kansas, 2095 Constant Avenue, 66047, Lawrence, Kansas aut NATIONALLICENCE 700 1- Perkins Melissa Department of Pharmaceutical Chemistry and, Center for Bioanalytical Research The University of Kansas, 2095 Constant Avenue, 66047, Lawrence, Kansas aut NATIONALLICENCE 700 1- Lunte Susan Department of Pharmaceutical Chemistry and, Center for Bioanalytical Research The University of Kansas, 2095 Constant Avenue, 66047, Lawrence, Kansas aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/4(1997-04-01), 372-387 0724-8741 14:4<372 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer