caa a22 4500 477127487 CHVBK 20180405111654.0 cr unu---uuuuu 170330e19970401xx s 000 0 eng 10.1023/A:1012078928297 doi (NATIONALLICENCE)springer-10.1023/A:1012078928297 Effect of Compaction Temperature on Consolidation of Amorphous Copolymers with Different Glass Transition Temperatures [Elektronische Daten] [K. Maarschalk, K. Zuurman, M. Van Steenbergen, W. Hennink, H. Vromans, G. Bolhuis, C. Lerk] Purpose. The purpose of this study was to relate the combination of glass transition temperature (T g) and temperature of measurement with the mechanical and compaction properties of some test materials. Methods. Copolymers with different T gs were synthesised by free radical copolymerisation of methyl methacrylate with lauryl methacrylate. Elastic moduli were measured by dynamic mechanical analysis at different strain rates and temperatures. Compaction experiments were performed at different compaction speeds and temperatures. Results. The difference between temperature of measurement and T g appears to determine both elastic modulus and yield strength completely. They both decrease with decreasing difference between temperature of measurement and Tg and increase with strain rate. At temperatures of measurement higher than the T g, the elastic modulus is extremely low because the materials behave as rubbers. Consequently, the amount of energy stored during compaction decreases when the compaction temperature approaches the T g and increases with strain rate. When the compaction temperature is higher than the T g, the amount of stored energy is extremely large. The compaction experiments show that the final tablet porosity is completely determined by stress relaxation phenomena. Consequently, the final tablet porosity follows exactly the same relation as that of stored energy. Conclusions. The final tablet porosity is unequivocally determined by the amount of stored energy. This implies that tablet production at a temperature of about 20 K under the glass transition temperature of the material yields tablets with minimum porosity. Plenum Publishing Corporation, 1997 tablet nationallicence copolymer nationallicence glass transition temperature nationallicence porosity nationallicence viscoelasticity nationallicence Maarschalk K. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut Zuurman K. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut Van Steenbergen M. Department of Pharmaceutics, University of Utrecht, The Netherlands aut Hennink W. Department of Pharmaceutics, University of Utrecht, The Netherlands aut Vromans H. N.V. Organon, Oss, The Netherlands aut Bolhuis G. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut Lerk C. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/4(1997-04-01), 415-419 0724-8741 14:4<415 1997 14 11095 https://doi.org/10.1023/A:1012078928297 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012078928297 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maarschalk K. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Zuurman K. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Van Steenbergen M. Department of Pharmaceutics, University of Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Hennink W. Department of Pharmaceutics, University of Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Vromans H. N.V. Organon, Oss, The Netherlands aut NATIONALLICENCE 700 1- Bolhuis G. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Lerk C. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Ant. Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/4(1997-04-01), 415-419 0724-8741 14:4<415 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer