caa a22 4500 477127673 CHVBK 20180405111654.0 cr unu---uuuuu 170330e19970801xx s 000 0 eng 10.1023/A:1012153328664 doi (NATIONALLICENCE)springer-10.1023/A:1012153328664 Consolidation Mechanisms of Pharmaceutical Solids: A Multi-Compression Cycle Approach [Elektronische Daten] [Davar Khossravi, William Morehead] Purpose. The consolidation behavior of various pharmaceutical solids were characterized using compression-cycle profiles. Compression-cycle profiles for both uncompacted powder and formed tablets were obtained. These profiles were used to qualitatively and quantitatively characterize the consolidation mechanism of pharmaceutical solids. Methods. An Instron Universal Testing apparatus and a specially instrumented die coupled with a computerized data acquisition system were utilized to measure the upper-punch pressure and the corresponding die-wall pressure during the compression cycle. Results. Compression cycle profiles were obtained for a variety of pharmaceutical materials. Based on these profiles, parameters such as hysteresis areas, loading slopes, and unloading slopes were calculated for the materials studied. Conclusions. Materials that consolidate by plastic deformation have similar compression cycle profiles for the first and subsequent compression cycles indicating that the plastic deformation process occurs to the same extent on the first as well as subsequent compression cycles. For brittle materials, the brittle fracture process occurs during the first compression cycle. During subsequent cycles the tabletted material does not undergo further yield or failure and primarily undergoes elastic deformation. Low molecular-weight polyethylene glycol is an excellent model material for plastically deforming materials, whereas sucrose or sodium citrate are excellent examples of materials that consolidate by brittle fracture. Plenum Publishing Corporation, 1997 compression cycle nationallicence consolidation mechanism nationallicence plastic deformation nationallicence brittle fracture nationallicence multiple compression nationallicence pharmaceutical excipients nationallicence Khossravi Davar 3M Pharmaceuticals, 3M Center, Bldg 260-4N-12, St. Paul, 55144-1000, Minnesota aut Morehead William Experimental Station, DuPont Merck, Pharmaceutical Research and Development, PO Box 80400, 19880, Wilmington, Delaware aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/8(1997-08-01), 1039-1045 0724-8741 14:8<1039 1997 14 11095 https://doi.org/10.1023/A:1012153328664 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012153328664 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khossravi Davar 3M Pharmaceuticals, 3M Center, Bldg 260-4N-12, St. Paul, 55144-1000, Minnesota aut NATIONALLICENCE 700 1- Morehead William Experimental Station, DuPont Merck, Pharmaceutical Research and Development, PO Box 80400, 19880, Wilmington, Delaware aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/8(1997-08-01), 1039-1045 0724-8741 14:8<1039 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer