caa a22 4500 47712772X CHVBK 20180405111654.0 cr unu---uuuuu 170330e19970801xx s 000 0 eng 10.1023/A:1012157429573 doi (NATIONALLICENCE)springer-10.1023/A:1012157429573 Circulatory Concentrations of Fibrinolytic Species During Thrombolytic Therapy Estimated by Stirred-Tank Reactor Analysis [Elektronische Daten] [Vinod Tbliani, Edgar O'Rear] Purpose. A model for calculating the circulatory concentrations of fibrinolytic species is proposed and the findings are compared to reported values where available. Methods. The model uses a CSTR analysis with fourth order Runge-Kutta solution of the differential equations to determine concentration profiles of key fibrinolytic species as a function of time during fibrinolytic therapy. Concentrations of the species are also determined for various dosage regimens of streptokinase and plasminogen. Results. Data calculated by the model is in agreement with general experimental trends determined in vitro and in vivo. Conclusions. The proposed model can be used to predict concentration profiles of key fibrinolytic species during administration of streptokinase. Plenum Publishing Corporation, 1997 streptokinase nationallicence fibrinolytic therapy nationallicence fibrinolytic agents nationallicence Tbliani Vinod Smith Kline Beecham Pharmaceuticals, 709 Swedeland Rd., 19406, Prussia, Pennsylvania aut O'Rear Edgar Department of Chemical Engineering, University of Oklahoma, Energy Center Rm. T335, 73019, Norman, Oklahoma aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/8(1997-08-01), 1051-1057 0724-8741 14:8<1051 1997 14 11095 https://doi.org/10.1023/A:1012157429573 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012157429573 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tbliani Vinod Smith Kline Beecham Pharmaceuticals, 709 Swedeland Rd., 19406, Prussia, Pennsylvania aut NATIONALLICENCE 700 1- O'Rear Edgar Department of Chemical Engineering, University of Oklahoma, Energy Center Rm. T335, 73019, Norman, Oklahoma aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/8(1997-08-01), 1051-1057 0724-8741 14:8<1051 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer