caa a22 4500 477127738 CHVBK 20180405111654.0 cr unu---uuuuu 170330e19970801xx s 000 0 eng 10.1023/A:1012188909100 doi (NATIONALLICENCE)springer-10.1023/A:1012188909100 Pharmacokinetic Analysis of Benzodiazepine Receptor Binding of [123I]Iomazenil in Human Brain [Elektronische Daten] [Kiyomi Ito, Toshimitsu Momose, Hajime Kotaki, Yoshiki Kojima, Koujirou Yamamoto, Masataka Katashima, Yasufumi Sawada, Yasuhito Sasaki, Tatsuji Iga] Purpose. The purpose of this study is to evaluate the central benzodiazepine (BZP) receptor binding of iomazenil (IMZ) by pharmacokinetic analysis and to establish a methodology for the diagnosis of CNS disorders with abnormalities in BZP receptor binding. Methods. BZP receptor binding of IMZ was analyzed kinetically using plasma concentration-time profiles and dynamic single photon emission computed tomography (SPECT) data obtained after the intravenous administration of IMZ to patients with neuropsychiatric diseases. The analysis was based on a 3-compartmental model including the processes of both blood-brain barrier (BBB) transport and BZP receptor binding. Results. Hydrolized metabolite of IMZ was detected in plasma, indicating the need for separation by HPLC. The BBB influx clearance and the receptor binding potential of IMZ in the medial temporal region was reduced in the epileptic patient. Conclusions. Our findings suggest the possibility of detecting the epileptic focus by using our method. Plenum Publishing Corporation, 1997 iomazenil nationallicence SPECT nationallicence benzodiazepine receptor nationallicence human nationallicence Ito Kiyomi Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut Momose Toshimitsu Department of Radiology, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut Kotaki Hajime Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut Kojima Yoshiki Department of Radiology, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut Yamamoto Koujirou Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut Katashima Masataka Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut Sawada Yasufumi Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Mai-dashi, Higashi-ku, 812, Fukuoka, Japan aut Sasaki Yasuhito Department of Radiology, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut Iga Tatsuji Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/8(1997-08-01), 999-1003 0724-8741 14:8<999 1997 14 11095 https://doi.org/10.1023/A:1012188909100 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012188909100 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ito Kiyomi Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Momose Toshimitsu Department of Radiology, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kotaki Hajime Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kojima Yoshiki Department of Radiology, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamamoto Koujirou Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Katashima Masataka Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Sawada Yasufumi Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Mai-dashi, Higashi-ku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sasaki Yasuhito Department of Radiology, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Iga Tatsuji Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 113, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/8(1997-08-01), 999-1003 0724-8741 14:8<999 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer