caa a22 4500 477127800 CHVBK 20180405111655.0 cr unu---uuuuu 170330e19970801xx s 000 0 eng 10.1023/A:1012161630481 doi (NATIONALLICENCE)springer-10.1023/A:1012161630481 Simultaneous In Vivo Visualization and Localization of Solid Oral Dosage Forms in the Rat Gastrointestinal Tract by Magnetic Resonance Imaging (MRI) [Elektronische Daten] [Vera Christmann, Jörg Rosenberg, Jürgen Seega, Claus-Michael Lehr] Purpose. Bioavailability of orally administered drugs is much influenced by the behavior, performance and fate of the dosage form within the gastrointestinal (GI) tract. Therefore, MRI in vivo methods that allow for the simultaneous visualization of solid oral dosage forms and anatomical structures of the GI tract have been investigated. Methods. Oral contrast agents containing Gd-DTPA were used to depict the lumen of the digestive organs. Solid oral dosage forms were visualized in a rat model by a 1H-MRI double contrast technique (magnetite-labelled microtablets) and a combination of 1H- and 19F-MRI (fluorine-labelled minicapsules). Results. Simultaneous visualization of solid oral dosage forms and the GI environment in the rat was possible using MRI. Microtablets could reproducibly be monitored in the rat stomach and in the intestines using a 1H-MRI double contrast technique. Fluorine-labelled minicapsules were detectable in the rat stomach by a combination of 1H- and 19F-MRI in vivo. Conclusions. The in vivo 1H-MRI double contrast technique described allows solid oral dosage forms in the rat GI tract to be depicted. Solid dosage forms can easily be labelled by incorporating trace amounts of non-toxic iron oxide (magnetite) particles. 1H-MRI is a promising tool for observing such pharmaceutical dosage forms in humans. Combined 1H- and 19F-MRI offer a means of unambiguously localizing solid oral dosage forms in more distal parts of the GI tract. Studies correlating MRI examinations with drug plasma levels could provide valuable information for the development of pharmaceutical dosage forms. Plenum Publishing Corporation, 1997 gastrointestinal transit nationallicence magnetic resonance imaging nationallicence nuclear magnetic resonance nationallicence oral drug delivery nationallicence solid oral dosage forms nationallicence Christmann Vera Knoll AG, Research and Development, P.O. Box 210805, 67008, Ludwigshafen, Germany aut Rosenberg Jörg Knoll AG, Research and Development, P.O. Box 210805, 67008, Ludwigshafen, Germany aut Seega Jürgen Knoll AG, Research and Development, P.O. Box 210805, 67008, Ludwigshafen, Germany aut Lehr Claus-Michael Knoll AG, Research and Development, P.O. Box 210805, 67008, Ludwigshafen, Germany aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/8(1997-08-01), 1066-1072 0724-8741 14:8<1066 1997 14 11095 https://doi.org/10.1023/A:1012161630481 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012161630481 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Christmann Vera Knoll AG, Research and Development, P.O. Box 210805, 67008, Ludwigshafen, Germany aut NATIONALLICENCE 700 1- Rosenberg Jörg Knoll AG, Research and Development, P.O. Box 210805, 67008, Ludwigshafen, Germany aut NATIONALLICENCE 700 1- Seega Jürgen Knoll AG, Research and Development, P.O. Box 210805, 67008, Ludwigshafen, Germany aut NATIONALLICENCE 700 1- Lehr Claus-Michael Knoll AG, Research and Development, P.O. Box 210805, 67008, Ludwigshafen, Germany aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/8(1997-08-01), 1066-1072 0724-8741 14:8<1066 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer