caa a22 4500 477127886 CHVBK 20180405111655.0 cr unu---uuuuu 170330e19970501xx s 000 0 eng 10.1023/A:1012136608249 doi (NATIONALLICENCE)springer-10.1023/A:1012136608249 Cyclodextrins: Their Future in Drug Formulation and Delivery [Elektronische Daten] [Valentine Stella, Roger Rajewski] Since their discovery, cyclodextrins and their ability to form inclusion complexes have fascinated chemists, formulators and recently, entrepreneurs. This mini-review has as its objective, a critical assessment of the current status of cyclodextrins in the formulation and delivery of pharmaceuticals and commentary on their potential future uses. The emphasis will be on answers to common questions often asked of pharmaceutical scientists working in this area. Why use cyclodextrins for drug solubilization and stabilization when alternative techniques are available? Why the greater interest in modified cyclodextrins and not the parent cyclodextrins? If a drug forms a strong cyclodextrin inclusion complex, how is the drug releasedin vivo? Does the injection of a cyclodextrin/drug complex alter the pharmacokinetics of the drug? Are there drug products on the market which contain cyclodextrins? What is the regulatory status of cyclodextrins? Although definitive answers to all these questions are not possible at this time, many of these questions are answerable, and educated and informed responses are possible for the rest. Plenum Publishing Corporation, 1997 cyclodextrins nationallicence drug formulation nationallicence drug delivery nationallicence pharmacokinetics nationallicence Stella Valentine Higuchi Biosciences Center for Drug Delivery Research and the Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, Kansas aut Rajewski Roger Higuchi Biosciences Center for Drug Delivery Research and the Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, Kansas aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/5(1997-05-01), 556-567 0724-8741 14:5<556 1997 14 11095 https://doi.org/10.1023/A:1012136608249 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012136608249 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stella Valentine Higuchi Biosciences Center for Drug Delivery Research and the Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, Kansas aut NATIONALLICENCE 700 1- Rajewski Roger Higuchi Biosciences Center for Drug Delivery Research and the Department of Pharmaceutical Chemistry, The University of Kansas, 66047, Lawrence, Kansas aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/5(1997-05-01), 556-567 0724-8741 14:5<556 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer