caa a22 4500 477128025 CHVBK 20180405111655.0 cr unu---uuuuu 170330e19970501xx s 000 0 eng 10.1023/A:1012192725996 doi (NATIONALLICENCE)springer-10.1023/A:1012192725996 Thermophysical Properties of Trehalose and Its Concentrated Aqueous Solutions [Elektronische Daten] [Danforth Miller, Juan de Pablo, Horacio Corti] Purpose. To address the lack of fundamental thermophysical data for trehalose and its aqueous systems by measuring equilibrium and non-equilibrium properties of such systems. Methods/Results. Differential scanning calorimetry (DSC) and dynamic mechanical analysis were used to measure glass transition temperatures of trehalose and its solutions. X-ray diffractometry was used to verify the structure of amorphous trehalose. Controlled-stress rheometry was used to measure viscosity of several aqueous trehalose systems at ambient and sub-ambient temperatures. Over this temperature range, the density of these solutions was also measured with a vibrating tube densimeter. The equilibrium phase diagram of aqueous trehalose was determined by measuring the solubility and freezing point depression. Conclusions. Our solubility measurements, which have allowed long times for attainment of chemical equilibrium, are substantially different from those reported earlier that used different techniques. Our measurements of the glass transition temperature of trehalose are higher than reported values. A simple model for the glass transition is presented to describe our experimental observations. Plenum Publishing Corporation, 1997 trehalose nationallicence phase diagram nationallicence glass transition nationallicence viscosity nationallicence molar volume nationallicence cryoprotection nationallicence Miller Danforth Department of Chemical Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, 53706, Madison, Wisconsin aut de Pablo Juan Department of Chemical Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, 53706, Madison, Wisconsin aut Corti Horacio Departamento de Química, C.N.E.A. and Institute de Química de Materiales, Medio Ambiente y Energía, Buenos Aires, Argentina aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/5(1997-05-01), 578-590 0724-8741 14:5<578 1997 14 11095 https://doi.org/10.1023/A:1012192725996 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012192725996 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miller Danforth Department of Chemical Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, 53706, Madison, Wisconsin aut NATIONALLICENCE 700 1- de Pablo Juan Department of Chemical Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, 53706, Madison, Wisconsin aut NATIONALLICENCE 700 1- Corti Horacio Departamento de Química, C.N.E.A. and Institute de Química de Materiales, Medio Ambiente y Energía, Buenos Aires, Argentina aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/5(1997-05-01), 578-590 0724-8741 14:5<578 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer