caa a22 4500 477128114 CHVBK 20180405111656.0 cr unu---uuuuu 170330e19970201xx s 000 0 eng 10.1023/A:1012052827872 doi (NATIONALLICENCE)springer-10.1023/A:1012052827872 Binding of Prednisolone and Its Ester Prodrugs in the Skin [Elektronische Daten] [Tomohiro Hikima, Kakuji Tojo] Purpose. Skin binding of prednisolone and its esters was investigated in the hairless mouse skin in vitro. Methods. The distribution of the amount of drugs bound in the skin was determined by a skin slicing technique. The model drugs used were prednisolone (PN, M.W. 360) and its esters, senesyonate (PN-C5, M.W. 442), geranate (PN-C10, M.W. 510), farnesylate (PN-C15, M.W. 578), and geranylgeranate (PN-C20, M.W. 646). Results. The distribution of bound drug was nonhomogeneous in the skin; the concentration of PN-C10 and PN-C15 in the skin increased gradually with the distance from the skin surface. The parent drug, PN, however, was hardly bound in the viable skin. Conclusions. These findings suggest that the prodrugs of prednisolone may prolong the dermal retention of the parent drug and minimize to delivery into the systemic circulation of the prodrug and metabolite. Plenum Publishing Corporation, 1997 skin binding nationallicence percutaneous absorption nationallicence prednisolone nationallicence prednisolone esters nationallicence Hikima Tomohiro aut Tojo Kakuji aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 197-202 0724-8741 14:2<197 1997 14 11095 https://doi.org/10.1023/A:1012052827872 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012052827872 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hikima Tomohiro aut NATIONALLICENCE 700 1- Tojo Kakuji aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 197-202 0724-8741 14:2<197 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer