caa a22 4500 477128149 CHVBK 20180405111656.0 cr unu---uuuuu 170330e19970201xx s 000 0 eng 10.1023/A:1012076022420 doi (NATIONALLICENCE)springer-10.1023/A:1012076022420 Applications of the Ion-Pair Concept to Hydrophilic Substances with Special Emphasis on Peptides [Elektronische Daten] [David Quintanar-Guerrero, Eric Allémann, Hatem Fessi, Erie Doelker] Previous investigations have shown that ionic drugs with high aqueous solubilities can be lipophilized by ion-pair formation, with appropriate counter-ions. This type of association may prove promising for several biopharmaceutical, analytical and technological applications. This review examines the ion-pair concept with special emphasis on its application to peptides. The conditions for ion-pair formation of different molecules, as well as their transfer to organic solvents, are described. The use of ion-pairs to increase the permeation of various therapeutic agents, including peptidic drugs, is also discussed. Recent uses of ion-pairs in micro- and nanoencapsulation of peptides are also commented upon. Plenum Publishing Corporation, 1997 ion-pair nationallicence peptides nationallicence counter ions nationallicence ion-pair extraction nationallicence ion-pair enhanced absorption nationallicence Quintanar-Guerrero David aut Allémann Eric aut Fessi Hatem aut Doelker Erie aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 119-127 0724-8741 14:2<119 1997 14 11095 https://doi.org/10.1023/A:1012076022420 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012076022420 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Quintanar-Guerrero David aut NATIONALLICENCE 700 1- Allémann Eric aut NATIONALLICENCE 700 1- Fessi Hatem aut NATIONALLICENCE 700 1- Doelker Erie aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 119-127 0724-8741 14:2<119 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 220399964 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer