caa a22 4500 477128173 CHVBK 20180405111656.0 cr unu---uuuuu 170330e19970201xx s 000 0 eng 10.1023/A:1012048626963 doi (NATIONALLICENCE)springer-10.1023/A:1012048626963 Activation of Signal Transduction Kinases by Tamoxifen [Elektronische Daten] [Jauh-Lin Duh, Rong Yu, Jie-Jun Jiao, George Matwyshyn, Wei Li, Tse-Hua Tan, A.-N. Kong] Purpose. To study the signal transduction mechanisms of tamoxifen via the activation of MAPKs, JNK and ERK in order to understand its regulation of gene expression. Methods. The effects of tamoxifen (TAM) on the activation of serine/ threonine mitogen-activated protein kinase (MAPK, p42/ERK2) and the stress-activated protein kinases (p46 SAPK or c-Jun N-terminal kinase, JNK1) were evaluated using a human cervical epitheloid carcinoma HeLa cell line. Results. TAM activated both JNK1 and ERK2 activities in a time- and dose-dependent manner in HeLa cells. The activation of JNK1 was enhanced when the cells were pretreated with prooxidant H2O2. Conclusions. These studies show that TAM activates the signal transduction kinases, JNK1 and ERK2, which may play important roles in the regulation of gene expression by TAM. Plenum Publishing Corporation, 1997 tamoxifen nationallicence MAP kinases nationallicence MAPK nationallicence JNK nationallicence ERK nationallicence AP-1 nationallicence ARE nationallicence NF-κB nationallicence signal transduction nationallicence Duh Jauh-Lin aut Yu Rong aut Jiao Jie-Jun aut Matwyshyn George aut Li Wei aut Tan Tse-Hua aut Kong A.-N aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 186-189 0724-8741 14:2<186 1997 14 11095 https://doi.org/10.1023/A:1012048626963 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012048626963 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Duh Jauh-Lin aut NATIONALLICENCE 700 1- Yu Rong aut NATIONALLICENCE 700 1- Jiao Jie-Jun aut NATIONALLICENCE 700 1- Matwyshyn George aut NATIONALLICENCE 700 1- Li Wei aut NATIONALLICENCE 700 1- Tan Tse-Hua aut NATIONALLICENCE 700 1- Kong A.-N aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 186-189 0724-8741 14:2<186 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer