caa a22 4500 477128246 CHVBK 20180405111656.0 cr unu---uuuuu 170330e19970201xx s 000 0 eng 10.1023/A:1012061029689 doi (NATIONALLICENCE)springer-10.1023/A:1012061029689 Formulation of a Charcoal Suspension for Intratumor Injection. Part 1: Study of the Nature, Granulometry, and Concentration [Elektronische Daten] [L. Bonhomme-Faivre, M. Mathieu, J. Grossiord, P. Depreatere, G. Couarraze, S. Orbach-Arbouys, F. Puisieux, M. Seiller] Purpose. We developed a charcoal suspension formulation to be injected intratumorally so that human breast cancers can be tatooed prior to chemotherapy. This deposit is intended to guide the surgeon at the time of the biopsy and resection, especially when the tumor nodule is not visible. The stain should remain in the tumor as long as the patient is on chemotherapy and should be harmless. Methods. We studied on the effect on the nature of the charcoal, its granulometric profile, and its concentration. We then measured diffusion in vitro, in gel, and in vivo in experimental tumors. Results. The formulation selected was prepared with a peat charcoal suspension in water for parenteral injections, with 50% of the particles measuring on average between 2 and 5 μm. The finest particles (<2 μm) seem to produce the greatest in vitro diffusion and are more readily phagocyted by macrophages and thus eliminated from the tumor by those cells. Conclusions. This charcoal suspension has satisfactory formulation characteristics and diffuses the least, be it in vitro or in vivo, mainly due to the granulometric distribution of the suspension. Plenum Publishing Corporation, 1997 charcoal nationallicence suspension nationallicence in vitro diffusion nationallicence in vivo labelling nationallicence mammary tumor nationallicence Bonhomme-Faivre L. aut Mathieu M. aut Grossiord J. aut Depreatere P. aut Couarraze G. aut Orbach-Arbouys S. aut Puisieux F. aut Seiller M. aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 218-223 0724-8741 14:2<218 1997 14 11095 https://doi.org/10.1023/A:1012061029689 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012061029689 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bonhomme-Faivre L. aut NATIONALLICENCE 700 1- Mathieu M. aut NATIONALLICENCE 700 1- Grossiord J. aut NATIONALLICENCE 700 1- Depreatere P. aut NATIONALLICENCE 700 1- Couarraze G. aut NATIONALLICENCE 700 1- Orbach-Arbouys S. aut NATIONALLICENCE 700 1- Puisieux F. aut NATIONALLICENCE 700 1- Seiller M. aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 218-223 0724-8741 14:2<218 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer