caa a22 4500 477128335 CHVBK 20180405111656.0 cr unu---uuuuu 170330e19970201xx s 000 0 eng 10.1023/A:1012056928780 doi (NATIONALLICENCE)springer-10.1023/A:1012056928780 The Equivalent Bronchodilator Effects of Salbutamol Formulated in Chlorofluorocarbon and Hydrofluoroalkane-134a Metered Dose Inhalers on the Histamine-Induced Pulmonary Response in Dogs [Elektronische Daten] [Mari Nogami-Itoh, Ikuhisa Yakuo, David Hammerbeck, Richard Miller, Kunihiko Takeyama] Purpose. The bronchodilator effect of salbutamol formulated in hydrofluoroalkane-134a (HFA-134a), a Chlorofluorocarbon (CFC)-free propellant for metered dose inhalation (MDI) devices, was compared with that of salbutamol formulated in CFC in anesthetized dogs. Methods. Bronchospasms were induced by the intravenous injection of histamine, and bronchial resistance was measured by the method of Konzett and Rossler. Results. While the placebo vehicles (HFA-134a and CFC propellants) had no significant effect on histamine-induced bronchospasms, the salbutamol/HFA-134a and salbutamol/CFC MDI formulations had equivalent dose-related inhibitory effects. Conclusions. These data indicated that salbutamol formulated in HFA-134a and that in CFC propellant are bioequivalent. Plenum Publishing Corporation, 1997 bioequivalent nationallicence salbutamol nationallicence hydrofluoroalkane-134a (HFA-134a) nationallicence Konzett-Rossler nationallicence Nogami-Itoh Mari aut Yakuo Ikuhisa aut Hammerbeck David aut Miller Richard aut Takeyama Kunihiko aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 208-212 0724-8741 14:2<208 1997 14 11095 https://doi.org/10.1023/A:1012056928780 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012056928780 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nogami-Itoh Mari aut NATIONALLICENCE 700 1- Yakuo Ikuhisa aut NATIONALLICENCE 700 1- Hammerbeck David aut NATIONALLICENCE 700 1- Miller Richard aut NATIONALLICENCE 700 1- Takeyama Kunihiko aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/2(1997-02-01), 208-212 0724-8741 14:2<208 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer