caa a22 4500 47712853X CHVBK 20180405111657.0 cr unu---uuuuu 170330e19971101xx s 000 0 eng 10.1023/A:1012113931332 doi (NATIONALLICENCE)springer-10.1023/A:1012113931332 Functional and Molecular Characteristics of Na+-dependent Nucleoside Transporters [Elektronische Daten] [Juan Wang, Marci Schaner, Silja Thomassen, Sheng-Fang Su, Micheline Piquette-Miller, Kathleen Giacomini] Nucleoside transporters play a critical role in the absorption, disposition, and targeting of therapeutically used nucleosides and nucleoside analogs. This review is focused on the Na+-dependent, concentrative nucleoside transporters which are found in a variety of cells including renal, intestinal and hepatic epithelia. Five major Na+-dependent nucleoside transporter subtypes have been characterized in isolated tissue preparations: Nl is purine selective; N2 is pyrimidine selective and N3−N5 exhibit variable selectivity for both purine and pyrimidine nucleosides. The recent cloning of Nl and N2 nucleoside transporters has provided the first information on the molecular function and structure of concentrative nucleoside transporters. In this manuscript we review the characteristics of the various subtypes of nucleoside transporters and the molecular structure, functional properties, and tissue distribution of the cloned Na+-dependent nucleoside transporters. In addition, the interactions of nucleosides and nucleoside analogs with the cloned transporters in mammalian and amphibian expression systems are presented. Mammalian expression systems may be particularly useful during drug development in screening potential compounds for improved bioavailability and tissue specific targeting. Finally, we present our view of future areas of study in the field of nucleoside transporters. Plenum Publishing Corporation, 1997 nucleoside transporters nationallicence review nationallicence nucleoside analogs nationallicence expression systems nationallicence adenosine nationallicence intestinal absorption nationallicence Wang Juan Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut Schaner Marci Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut Thomassen Silja Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut Su Sheng-Fang Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut Piquette-Miller Micheline School of Pharmacy, University of Toronto, Toronto, Ontario, Canada aut Giacomini Kathleen Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/11(1997-11-01), 1524-1532 0724-8741 14:11<1524 1997 14 11095 https://doi.org/10.1023/A:1012113931332 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012113931332 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Juan Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut NATIONALLICENCE 700 1- Schaner Marci Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut NATIONALLICENCE 700 1- Thomassen Silja Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut NATIONALLICENCE 700 1- Su Sheng-Fang Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut NATIONALLICENCE 700 1- Piquette-Miller Micheline School of Pharmacy, University of Toronto, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Giacomini Kathleen Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, San Francisco, California aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/11(1997-11-01), 1524-1532 0724-8741 14:11<1524 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer