caa a22 4500 477128572 CHVBK 20180405111657.0 cr unu---uuuuu 170330e19971101xx s 000 0 eng 10.1023/A:1012105713585 doi (NATIONALLICENCE)springer-10.1023/A:1012105713585 Rodrigues A. Drug Metabolism (Preclinical), Merck Research Laboratories, Sumneytown Pike, P.O. Box 4, WP26A 2044, 19486-0004, West Point, Pennsylvania aut Preclinical Drug Metabolism in the Age of High-Throughput Screening: An Industrial Perspective [Elektronische Daten] [A. Rodrigues] With the advent of genomics, combinatorial paradigms and high-throughput screen (HTS)-based pharmacological testing, the number of compounds flowing through the discovery pipeline is likely to escalate. At the same time, with increased knowledge of the human drug-metabolizing enzymes and the availability of in vitro absorption-metabolism (AM) models, Preclinical Drug Metabolism is poised to meet the challenges of HTS. In order to be successful, however, a rational HTS strategy (vs. serendipitous HTS) has to be employed. Such a strategy is based on automation, validation and integration of in vitroAM models and database management (AVID). A generalized strategy for rational (AVID-based) HTS in Preclinical Drug Metabolism is described briefly. Plenum Publishing Corporation, 1997 high-throughput nationallicence in vitro models nationallicence in vitro-in vivo correlations nationallicence metabolism nationallicence absorption nationallicence drug discovery nationallicence screening nationallicence Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/11(1997-11-01), 1504-1510 0724-8741 14:11<1504 1997 14 11095 https://doi.org/10.1023/A:1012105713585 text/html Onlinezugriff via DOI 1 article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1012105713585 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rodrigues A. Drug Metabolism (Preclinical), Merck Research Laboratories, Sumneytown Pike, P.O. Box 4, WP26A 2044, 19486-0004, West Point, Pennsylvania aut NATIONALLICENCE 773 0- Pharmaceutical Research Kluwer Academic Publishers-Plenum Publishers 14/11(1997-11-01), 1504-1510 0724-8741 14:11<1504 1997 14 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer