caa a22 4500 477128637 CHVBK 20180405111657.0 cr unu---uuuuu 170330e19970101xx s 000 0 eng 10.1023/A:1018470802969 doi (NATIONALLICENCE)springer-10.1023/A:1018470802969 Dietary and tobacco risk factors for adult onset glioma in the San Francisco Bay Area (California, USA) [Elektronische Daten] [Marion Lee, Margaret Wrensch, Rei Miike] The roles of diet and tobacco in the etiology of primary brain cancer are controversial. In this report, we compare dietary and cigarette smoking histories among 434 adults newly diagnosed with glioma in the San Francisco Bay Area (California, USA) between 1991 and 1994 with frequency age, gender, and ethnicity-matched population-based controls. Data were obtained on use of vitamin supplements and mean weekly consumption of each of 24 food groups. Adjusted for age, family income, and education, for both men and women, cases had higher mean weekly consumption of cured meats and other cured foods, lower consumption of high vitamin A and C fruits and vegetables, and higher average intakes of beer and other alcohol than controls. Men with brain cancer were twice as likely as control men to report high consumption of cured foods and low consumption of foods rich in vitamin C (odds ratio [OR]=2.0, 95 percent confidence interval [CI]=1.2-3.5). This association was less pronounced and not statistically significant in women (OR=1.5, CI=0.8-2.7). Similarly, men with brain cancer were twice as likely as controls to have high nitrite and low vitamin C consumption. Among men only, cases were 1.8 times more likely than controls to report smoking unfiltered cigarettes (CI=0.9-3.4). Moreover, among smokers, cases smoked unfiltered cigarettes almost twice as long as controls (P=0.04) and cases' average total pack-years also significantly exceeded controls. Although these findings support the hypothesis that N-nitroso compounds might be a factor in adult glioma, they are compatible with other dietary hypotheses. In particular, these results also favor the hypothesis that total body burden of oxidants may play a role in brain cancer causation. Chapman and Hall, 1997 Diet nationallicence glioma nationallicence tobacco nationallicence United States nationallicence Lee Marion School of Medicine, Department of Epidemiology and Biostatistics, University of California, San Francisco, USA aut Wrensch Margaret School of Medicine, Department of Epidemiology and Biostatistics, University of California, San Francisco, USA aut Miike Rei School of Medicine, Department of Epidemiology and Biostatistics, University of California, San Francisco, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/1(1997-01-01), 13-24 0957-5243 8:1<13 1997 8 10552 https://doi.org/10.1023/A:1018470802969 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018470802969 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Marion School of Medicine, Department of Epidemiology and Biostatistics, University of California, San Francisco, USA aut NATIONALLICENCE 700 1- Wrensch Margaret School of Medicine, Department of Epidemiology and Biostatistics, University of California, San Francisco, USA aut NATIONALLICENCE 700 1- Miike Rei School of Medicine, Department of Epidemiology and Biostatistics, University of California, San Francisco, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/1(1997-01-01), 13-24 0957-5243 8:1<13 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer