caa a22 4500 47712867X CHVBK 20180405111657.0 cr unu---uuuuu 170330e19970101xx s 000 0 eng 10.1023/A:1018483121625 doi (NATIONALLICENCE)springer-10.1023/A:1018483121625 Environmental tobacco smoke and lung cancer mortality in the American Cancer Society's Cancer Prevention Study II [Elektronische Daten] [Victor Cardenas, Michael Thun, Harland Austin, Cathy Lally, W. Clark, Raymond Greenberg, Clark Heath Jr.] Environmental tobacco smoke (ETS) has been classified as a human lung carcinogen by the United States Environmental Protection Agency (EPA), based both on the chemical similarity of sidestream and mainstream smoke and on slightly higher lung cancer risk in never-smokers whose spouses smoke compared with those married to nonsmokers. We evaluated the relation between ETS and lung cancer prospectively in the US, among 114,286 female and 19,549 male never-smokers, married to smokers, compared with about 77,000 female and 77,000 male never-smokers whose spouses did not smoke. Multivariate analyses, based on 247 lung cancer deaths, controlled for age, race, diet, and occupation. Dose-response analyses were restricted to 92,222 women whose husbands provided complete information on cigarette smoking and date of marriage. Lung cancer death rates, adjusted for other factors, were 20 percent higher among women whose husbands ever smoked during the current marriage than among those married to never-smokers (relative risk [RR]=1.2, 95 percent confidence interval [CI]=0.8-1.6). For never-smoking men whose wives smoked, the RR was 1.1 (CI=0.6-1.8). Risk among women was similar or higher when the husband continued to smoke (RR=1.2, CI=0.8-1.8), or smoked 40 or more cigarettes per day (RR=1.9, CI=1.0-3.6), but did not increase with years of marriage to a smoker. Most CIs included the null. Although generally not statistically significant, these results agree with the EPA summary estimate that spousal smoking increases lung cancer risk by about 20 percent in never-smoking women. Even large prospective studies have limited statistical power to measure precisely the risk from ETS. Chapman and Hall, 1997 Lung cancer nationallicence environmental tobacco smoke nationallicence nonsmokers nationallicence United States nationallicence Cardenas Victor Epidemiology Division, Rollins School of Public Health, Emory University, Atlanta, USA aut Thun Michael Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, USA aut Austin Harland Epidemiology Division, Rollins School of Public Health, Emory University, Atlanta, USA aut Lally Cathy Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, USA aut Clark W. Epidemiology Division, Rollins School of Public Health, Emory University, Atlanta, USA aut Greenberg Raymond Epidemiology Division, Rollins School of Public Health, Emory University, Atlanta, USA aut Heath Jr. Clark Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/1(1997-01-01), 57-64 0957-5243 8:1<57 1997 8 10552 https://doi.org/10.1023/A:1018483121625 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018483121625 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cardenas Victor Epidemiology Division, Rollins School of Public Health, Emory University, Atlanta, USA aut NATIONALLICENCE 700 1- Thun Michael Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, USA aut NATIONALLICENCE 700 1- Austin Harland Epidemiology Division, Rollins School of Public Health, Emory University, Atlanta, USA aut NATIONALLICENCE 700 1- Lally Cathy Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, USA aut NATIONALLICENCE 700 1- Clark W. Epidemiology Division, Rollins School of Public Health, Emory University, Atlanta, USA aut NATIONALLICENCE 700 1- Greenberg Raymond Epidemiology Division, Rollins School of Public Health, Emory University, Atlanta, USA aut NATIONALLICENCE 700 1- Heath Jr Clark Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/1(1997-01-01), 57-64 0957-5243 8:1<57 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer