caa a22 4500 477128726 CHVBK 20180405111657.0 cr unu---uuuuu 170330e19970101xx s 000 0 eng 10.1023/A:1018431104786 doi (NATIONALLICENCE)springer-10.1023/A:1018431104786 Non-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer [Elektronische Daten] [David Hunter, Donna Spiegelman, Hans-Olov Adami, Piet van den Brandt, Aaron Folsom, R. Goldbohm, Saxon Graham, Goeffrey Howe, Lawrence Kushi, James Marshall, Anthony Miller, Frank Speizer, Walter Willett, Alicja Wolk, Shiaw-Shyuan Yaun] To assess more precisely the relative risks associated with established risk factors for breast cancer, and whether the association between dietary fat and breast cancer risk varies according to levels of these risk factors, we pooled primary data from six prospective studies in North America and Western Europe in which individual estimates of dietary fat intake had been obtained by validated food-frequency questionnaires. Based on information from 322,647 women among whom 4,827 cases occurred during follow-up: the multivariate-adjusted risk of late menarche (age15 years or more compared with under 12) was 0.72 (95 percent confidence interval [CI]=0.62-0.82); of being postmenopausal was 0.82 (CI=0.69-0.97); of high parity (three or more births compared with none) was 0.72 (CI=0.61-0.86); of late age at first birth (over 30 years of age compared with 20 or under) was 1.46 (CI=1.22-1.75); of benign breast disease was 1.53 (CI=1.41-1.65); of maternal history of breast cancer was 1.38 (CI=1.14-1.67); and history of a sister with breast cancer was 1.47 (CI=1.27-1.70). Greater duration of schooling (more than high-school graduation compared with less than high-school graduation) was associated significantly with higher risk in age-adjusted analyses, but was attenuated after controlling for other risk factors. Total fat intake (adjusted for energy consumption) was not associated significantly with breast cancer risk in any strata of these non-dietary risk factors. We observed a marginally significant interaction between total fat intake and risk of breast cancer according to history of benign breast disease, with fat intake being associated nonsignificantly positively with risk among women with a previous history of benign breast disease; no other significant interactions were observed. Risks for reproductive factors were similar to those observed in case-control studies; relative risks for family history of breast cancer were lower. We found no clear evidence in any subgroups of a major relation between total energy-adjusted fat intake and breast cancer. Chapman and Hall, 1997 Breast cancer nationallicence diet nationallicence reproductive factors nationallicence women nationallicence Hunter David Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA aut Spiegelman Donna Department of Epidemiology, Harvard School of Public Health, Boston, USA aut Adami Hans-Olov Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut van den Brandt Piet Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut Folsom Aaron Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA aut Goldbohm R. Department of Epidemiology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands aut Graham Saxon Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, USA aut Howe Goeffrey NCIC Epidemiology Unit, Department of Preventive Medicine and Biostatistics, Faculty of Medicine, University of Toronto, Toronto, Canada aut Kushi Lawrence Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA aut Marshall James Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, USA aut Miller Anthony NCIC Epidemiology Unit, Department of Preventive Medicine and Biostatistics, Faculty of Medicine, University of Toronto, Toronto, Canada aut Speizer Frank Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA aut Willett Walter Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA aut Wolk Alicja Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut Yaun Shiaw-Shyuan Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/1(1997-01-01), 49-56 0957-5243 8:1<49 1997 8 10552 https://doi.org/10.1023/A:1018431104786 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018431104786 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hunter David Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Spiegelman Donna Department of Epidemiology, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Adami Hans-Olov Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 700 1- van den Brandt Piet Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Folsom Aaron Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA aut NATIONALLICENCE 700 1- Goldbohm R. Department of Epidemiology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands aut NATIONALLICENCE 700 1- Graham Saxon Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, USA aut NATIONALLICENCE 700 1- Howe Goeffrey NCIC Epidemiology Unit, Department of Preventive Medicine and Biostatistics, Faculty of Medicine, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Kushi Lawrence Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA aut NATIONALLICENCE 700 1- Marshall James Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, USA aut NATIONALLICENCE 700 1- Miller Anthony NCIC Epidemiology Unit, Department of Preventive Medicine and Biostatistics, Faculty of Medicine, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Speizer Frank Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Willett Walter Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Wolk Alicja Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 700 1- Yaun Shiaw-Shyuan Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/1(1997-01-01), 49-56 0957-5243 8:1<49 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer