caa a22 4500 477128734 CHVBK 20180405111657.0 cr unu---uuuuu 170330e19970101xx s 000 0 eng 10.1023/A:1018479020716 doi (NATIONALLICENCE)springer-10.1023/A:1018479020716 Height, weight, weight change, and postmenopausal breast cancer risk: the Netherlands Cohort Study [Elektronische Daten] [Piet van den Brandt, Miranda Dirx, Cécile Ronckers, Peggy van den Hoogen, R. Goldbohm] The association between several anthropometric indices and breast cancer risk was evaluated within the Netherlands Cohort Study on diet and cancer, which began in 1986 and is conducted among 62,573 women aged 55 to 69 years at baseline. After 4.3 years of follow-up, data on 626 women with incident breast cancer were available with complete information on height and weight at baseline. In multivariate case-cohort analyses, a significantly positive association between adult height and breast cancer was found (P trend < 0.001). Compared with women with height ≤ 155 cm, the rate ratios of breast cancer for women with heights up to 160, 165, 170, 175, and ≥ 175 cm were 1.22, 1.19, 1.44, 1.77, and 2.06, respectively. For weight at baseline, the significant positive association with breast cancer observed in age-adjusted analysis disappeared in multivariate analysis with adjustment for height and other confounders. For body mass index (BMI) (wt[kg]/ht[m]2) at baseline, no association was observed with breast cancer in multivariate analysis; compared with women with a BMI less than 23, the RR for women with a BMI of 30 or more was 0.98 with P trend=0.46. Weight and BMI at age 20 showed weak inverse associations with breast cancer risk. For gain in weight or BMI between age 20 and cohort baseline age, inconsistent increases in risk were found, with no significant trends. These data support a positive association between height and breast cancer risk among postmenopausal women. Further study is needed to evaluate the role of early diet and breast cancer in this population, and its relationship to height. Chapman and Hall, 1997 Breast neoplasms nationallicence body height nationallicence body weight nationallicence Netherlands nationallicence weight gain nationallicence women nationallicence van den Brandt Piet Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut Dirx Miranda Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut Ronckers Cécile Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut van den Hoogen Peggy Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut Goldbohm R. Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut Cancer Causes & Control Kluwer Academic Publishers 8/1(1997-01-01), 39-47 0957-5243 8:1<39 1997 8 10552 https://doi.org/10.1023/A:1018479020716 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018479020716 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van den Brandt Piet Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Dirx Miranda Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Ronckers Cécile Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut NATIONALLICENCE 700 1- van den Hoogen Peggy Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Goldbohm R. Department of Epidemiology, University of Limburg Maastricht, The Netherlands aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/1(1997-01-01), 39-47 0957-5243 8:1<39 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer