caa a22 4500 47712884X CHVBK 20180405111657.0 cr unu---uuuuu 170330e19971101xx s 000 0 eng 10.1023/A:1018420513815 doi (NATIONALLICENCE)springer-10.1023/A:1018420513815 Parity and other reproductive factors and risk of adenomatous polyps of the distal colorectum (United States) [Elektronische Daten] [Elizabeth Platz, Maria Martinez, Francine Grodstein, Charles Fuchs, Graham Colditz, Meir Stampfer, Edward Giovannucci] Evidence for an effect of reproductive factors on colorectal carcinogenesis is inconsistent and little is known about their role in development of precursor adenomatous polyps. We evaluated the relation between reproductive factors and distal colorectal adenomas (n = 982) during14 years of follow up of 26,983 participants in the Nurses' Health Study(United States). The women were free of diagnosed cancer or polyps in 1980,underwent endoscopy 1980-94, and had reported on their parity, oral contraceptive (OC) use, and ages at menarche, first term-pregnancy, and menopause. We calculated relative risks (RR) and 95 percent confidence intervals (CI) using multiple logistic regression. Women with higher parity had an increased risk of adenomas of the distal colorectum (P trend = 0.004;6+ cf 0 parity: RR = 1.3, CI = 0.9-1.8) or distal colon (P trend = 0.002, RR= 1.7, CI = 1.2-2.6). This association was significantly stronger among women with a family history of colorectal cancer ( P interaction = 0.03); comparing6+ term-pregnancies with nulliparity, among those with a family history, the RR for distal colon adenoma was 3.2 (CI = 1.4-7.2), while among those without a family history, the RR was 1.3 (CI = 0.8-2.2). We observed no association for distal colorectal adenoma and age at menarche, age at first term-pregnancy, ever use of OCs, or menopausal status. Further work is needed to clarify the relation of parity with colon adenoma risk. Chapman and Hall, 1997 Adenoma nationallicence colorectum nationallicence menopause nationallicence oral contraceptive nationallicence parity nationallicence polyp nationallicence reproductive factors nationallicence United States nationallicence women nationallicence Platz Elizabeth Department of Epidemiology, Harvard School of Public Health, Boston, USA aut Martinez Maria Department of Nutrition, Harvard School of Public Health, Boston, USA aut Grodstein Francine Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham & Women's Hospital, Boston, USA aut Fuchs Charles Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham & Women's Hospital, Boston, USA aut Colditz Graham Department of Epidemiology, Harvard School of Public Health, Boston, USA aut Stampfer Meir Department of Epidemiology, Harvard School of Public Health, Boston, USA aut Giovannucci Edward Department of Nutrition, Harvard School of Public Health, Boston, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/6(1997-11-01), 894-903 0957-5243 8:6<894 1997 8 10552 https://doi.org/10.1023/A:1018420513815 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018420513815 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Platz Elizabeth Department of Epidemiology, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Martinez Maria Department of Nutrition, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Grodstein Francine Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham & Women's Hospital, Boston, USA aut NATIONALLICENCE 700 1- Fuchs Charles Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham & Women's Hospital, Boston, USA aut NATIONALLICENCE 700 1- Colditz Graham Department of Epidemiology, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Stampfer Meir Department of Epidemiology, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Giovannucci Edward Department of Nutrition, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/6(1997-11-01), 894-903 0957-5243 8:6<894 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer