caa a22 4500 477128866 CHVBK 20180405111658.0 cr unu---uuuuu 170330e19971101xx s 000 0 eng 10.1023/A:1018476631561 doi (NATIONALLICENCE)springer-10.1023/A:1018476631561 Endogenous estrogen and postmenopausal breast cancer: a quantitative review [Elektronische Daten] [Hollie Thomas, Gillian Reeves, Timothy Key] This paper systematically reviews the results from epidemiologic studies investigating the hypothesis that breast cancer risk inpostmenopausal women increases with increasing concentrations of estradiol in blood and with increasing urinary estrogen excretion rates. Data from 29epidemiologic studies of endogenous hormones and postmenopausal breast cancer were used. The ratio of the average estrogen concentration in the women with breast cancer to that in the women without breast cancer (and its 95 percent confidence interval [CI]) was calculated for each study, and the results were summarized by calculating weighted averages of the log ratios. In six prospective studies of serum estradiol concentration, 329 women who subsequently developed breast cancer had, overall, a 15 percent (CI = 6-24percent, P = 0.0003) higher mean concentration of estradiol in their blood than the 1,105 women who remained free of cancer. The results of these prospective studies did not differ significantly from each other(chi-squared for heterogeneity = 8.7; degrees of freedom = 5; P > 0.1).Similar differences in mean estrogen levels were seen in the case-control studies which reported either estradiol concentrations in the blood or urinary estrogen excretion. However, the case-control studies showed significant heterogeneity among their results. The data from the prospective studies strongly suggest that breast cancer risk in postmenopausal women is associated with relatively high concentrations of endogenous estradiol. Chapman and Hall, 1997 Breast cancer nationallicence estrogen nationallicence postmenopausal nationallicence review nationallicence women nationallicence Thomas Hollie Cancer Epidemiology Unit, Imperial Cancer Research Fund, Oxford, UK aut Reeves Gillian Cancer Epidemiology Unit, Imperial Cancer Research Fund, Oxford, UK aut Key Timothy Cancer Epidemiology Unit, Imperial Cancer Research Fund, Oxford, UK aut Cancer Causes & Control Kluwer Academic Publishers 8/6(1997-11-01), 922-928 0957-5243 8:6<922 1997 8 10552 https://doi.org/10.1023/A:1018476631561 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018476631561 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thomas Hollie Cancer Epidemiology Unit, Imperial Cancer Research Fund, Oxford, UK aut NATIONALLICENCE 700 1- Reeves Gillian Cancer Epidemiology Unit, Imperial Cancer Research Fund, Oxford, UK aut NATIONALLICENCE 700 1- Key Timothy Cancer Epidemiology Unit, Imperial Cancer Research Fund, Oxford, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/6(1997-11-01), 922-928 0957-5243 8:6<922 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer