caa a22 4500 477128939 CHVBK 20180405111658.0 cr unu---uuuuu 170330e19970501xx s 000 0 eng 10.1023/A:1018477809755 doi (NATIONALLICENCE)springer-10.1023/A:1018477809755 Fujii Tomoko Teikyo University School of Medicine, Tokyo, 2-11-1, Kaga, Itabashi-ku Tokyo, Japan aut Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring [Elektronische Daten] [Tomoko Fujii] In order to prevent health risk from environmental chemicals, particularly for progeny, we have been performing a risk assessment for various chemicals including therapeutic agents. This paper reports the functional effects of maternal exposure to psychoactive drugs, anticancer drugs, or herbicides on the offspring of rats. Maternal exposure to imipramine in a dose equivalent to the therapeutic dose per unit body weight induced hyperthermic response to chlorpromazine in the male offspring, while normal control rats showed a marked hypothermia. Exposure to ethosuximide resulted in an increase in play fighting behavior in young offspring that was fostered by lactating normal mothers. Single exposures to nimustine or cisplatin, anticancer drugs, at a different gestational stage resulted in an acceleration of growth when exposed at the earlier stage of gestation. Moreover, cisplatin-exposed rats were emotionally unstable, showing a short latent time to the first line-crossing in an open-field during infantile period. The rats exposed to glufosinate ammonium, an herbicide, during the time of neurogenesis in the hippocampus showed a decrease in the wet-dog shakes response to kainic acid at six weeks of age. These results suggest that maternal exposure to chemicals during pregnancy induces a variety of functional abnormalities in the brain of the offspring dependent on the pharmacologic action of chemicals and the stage of gestation even with a single exposure. Chapman and Hall, 1997 Maternal chemical exposure nationallicence maternal drug exposure nationallicence rat offspring behavior nationallicence Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 524-528 0957-5243 8:3<524 1997 8 10552 https://doi.org/10.1023/A:1018477809755 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018477809755 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Fujii Tomoko Teikyo University School of Medicine, Tokyo, 2-11-1, Kaga, Itabashi-ku Tokyo, Japan aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 524-528 0957-5243 8:3<524 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer