caa a22 4500 477129064 CHVBK 20180405111658.0 cr unu---uuuuu 170330e19970501xx s 000 0 eng 10.1023/A:1018465507029 doi (NATIONALLICENCE)springer-10.1023/A:1018465507029 Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons [Elektronische Daten] [Paolo Boffetta, Nadia Jourenkova, Per Gustavsson] Epidemiologic evidence on the relationship between polycyclic aromatic hydrocarbons (PAH) and cancer is reviewed. High occupational exposure to PAHs occurs in several industries and occupations. Covered here are aluminum production, coal gasification, coke production, iron and steel foundries, tar distillation, shale oil extraction, wood impregnation, roofing, road paving, carbon black production, carbon electrode production, chimney sweeping, and calcium carbide production. In addition, workers exposed to diesel engine exhaust in the transport industry and in related occupations are exposed to PAHs and nitro-PAHs. Heavy exposure to PAHs entails a substantial risk of lung, skin, and bladder cancer, which is not likely to be due to other carcinogenic exposures present in the same industries. The lung seems to be the major target organ of PAH carcinogenicity and increased risk is present in most of the industries and occupations listed above. An increased risk of skin cancer follows high dermal exposure. An increase in bladder cancer risk is found mainly in industries with high exposure to PAHs from coal tars and pitches. Increased risks have been reported for other organs, namely the larynx and the kidney; the available evidence, however, is inconclusive. The results of studies addressing environmental PAH exposure are consistent with these conclusions. Chapman and Hall, 1997 Bladder cancer nationallicence lung cancer nationallicence occupational exposures nationallicence polycyclic aromatic hydrocarbons nationallicence skin cancer nationallicence Boffetta Paolo Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer, Lyon, France aut Jourenkova Nadia Department of Medical Statistics of the Institute Gustave-Roussy Villejuif, France aut Gustavsson Per Department of Occupational Health, Karolinska Hospital, Stockholm, Sweden aut Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 444-472 0957-5243 8:3<444 1997 8 10552 https://doi.org/10.1023/A:1018465507029 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018465507029 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boffetta Paolo Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer, Lyon, France aut NATIONALLICENCE 700 1- Jourenkova Nadia Department of Medical Statistics of the Institute Gustave-Roussy Villejuif, France aut NATIONALLICENCE 700 1- Gustavsson Per Department of Occupational Health, Karolinska Hospital, Stockholm, Sweden aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 444-472 0957-5243 8:3<444 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer