caa a22 4500 477129072 CHVBK 20180405111658.0 cr unu---uuuuu 170330e19970501xx s 000 0 eng 10.1023/A:1018421724776 doi (NATIONALLICENCE)springer-10.1023/A:1018421724776 Genetic susceptibility to environmental and occupational cancers [Elektronische Daten] [Naoko Ishibe, Karl Kelsey] Epidemiologic evidence on the relation between genetic susceptibility and cancer is reviewed. Traditional epidemiologic studies have identified various exposure-related associations with cancer. Most conventional approaches to environmental and occupational cancer have not been able to address specifically the issue of individual susceptibility to the action of carcinogens. However, with the recent rapid advances in molecular biology, novel approaches to define the role of genetic susceptibility in epidemiologic studies of cancer etiology have emerged. Molecular epidemiology has begun to develop within the broad field of cancer research. Here, we provide a description of the current framework of this research. Ongoing studies of the associations of inheritable polymorphisms in metabolic genes with specific carcinogen exposures reflect the most active area of research. Future efforts will include the examination of inherited variation in DNA repair. Methods are being developed n ow that will allow for the application of linkage analysis to the problem of gene-environment interaction in cancer. These approaches hold considerable promise for defining the nature of genetic susceptibility to exposure-related cancers. Chapman and Hall, 1997 Carcinogenesis nationallicence genetic susceptibility nationallicence molecular epidemiology nationallicence Ishibe Naoko Departments of Epidemiology and Environmental Health, Harvard School of Public Health and the Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, USA aut Kelsey Karl Departments of Environmental Health and Cancer Biology and the Harvard Center for Cancer Prevention, Harvard School of Public Health; Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 504-513 0957-5243 8:3<504 1997 8 10552 https://doi.org/10.1023/A:1018421724776 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018421724776 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishibe Naoko Departments of Epidemiology and Environmental Health, Harvard School of Public Health and the Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Kelsey Karl Departments of Environmental Health and Cancer Biology and the Harvard Center for Cancer Prevention, Harvard School of Public Health; Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 504-513 0957-5243 8:3<504 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer