caa a22 4500 477129099 CHVBK 20180405111658.0 cr unu---uuuuu 170330e19970501xx s 000 0 eng 10.1023/A:1018425825684 doi (NATIONALLICENCE)springer-10.1023/A:1018425825684 Linking genes and environmental exposure: why China presents special opportunities [Elektronische Daten] [Xiping Xu, Nicholas Schork] The Human Genome Project will have an enormous impact on our ability to study and understand human disease by providing maps of human genes. However, many of the most prevalent human diseases result from the complex interaction of numerous genes. Even with the use of a catalogue of human genes, the task of analyzing complex genetic and environmental interactions involved in the common human disorders will be formidable. Due to its demographic specificities and large size, the Chinese population offers a unique resource for the study of human genetics and the ability to capitalize upon the recent revolution in biotechnology. Reasons that China provides an exceptional population for genetic studies of complex diseases include: (i) the resource of 1.3 billion people makes obtaining a large number of subjects with rare (and common) diseases possible; (ii) relative genetic homogeneity in many regions has been preserved; (iii) stratification is distinct; (iv) urban/rural and geograph ic contrasts, both in environmental factors and disease occurrence, are quite marked; (v) family members tend to stay congregated; and (vi) epidemiologic study is cost-beneficial. Chapman and Hall, 1997 China nationallicence environment nationallicence genetic mapping nationallicence population genetics nationallicence Xu Xiping Departments of Environmental Health and Epidemiology, Program for Population Genetics, Harvard School of Public Health, Boston, USA aut Schork Nicholas Program for Population Genetics, Harvard School of Public Health, Boston, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 518-523 0957-5243 8:3<518 1997 8 10552 https://doi.org/10.1023/A:1018425825684 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018425825684 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xu Xiping Departments of Environmental Health and Epidemiology, Program for Population Genetics, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Schork Nicholas Program for Population Genetics, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 518-523 0957-5243 8:3<518 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer