caa a22 4500 477129102 CHVBK 20180405111658.0 cr unu---uuuuu 170330e19970501xx s 000 0 eng 10.1023/A:1018461406120 doi (NATIONALLICENCE)springer-10.1023/A:1018461406120 Organic solvents and cancer [Elektronische Daten] [Elsebeth Lynge, Ahti Anttila, Kari Hemminki] Epidemiologic evidence on the relationship between organic solvents and cancer is reviewed. In the 1980s, more than a million persons were potentially exposed to some specific solvents in the United States; in Canada, 40 percent of male cancer patients in Montreal had experienced exposure to solvents; in the Finnish population, one percent was regularly exposed. There is evidence for increased risks of cancer following exposure to: trichloroethylene (for the liver and biliary tract and for non-Hodgkin's lymphomas); tetrachloroethylene (for the esophagus and cervix - although confounding by smoking, alcohol, and sexual habits cannot be excluded - and non-Hodgkin's lymphoma); and carbon tetrachloride (lymphohematopoietic malignancies). An excess risk of liver and biliary tract cancers was suggested in the cohort with the high exposure to methylene chloride, but not found in the other cohorts where an excess risk of pancreatic cancer was suggested. 1,1,1-trichloroethane has been used widely, but only a few studies have been done suggesting a risk of multiple myeloma. A causal association between exposure to benzene and an increased risk of leukemia is well-established, as well as a suggested risk of lung and nasopharynx cancer in a Chinese cohort. Increased risks of various gastrointestinal cancers have been suggested following exposure to toluene. Two informative studies indicated an increased risk of lung cancer, not supported by other studies. Increased risks of lymphohematopoietic malignancies have been reported in some studies of persons exposed to toluene or xylene, but not in the two most informative studies on toluene. Occupation as a painter has consistently been associated with a 40 percent increased risk of lung cancer. (With the mixed exposures, however, it is not possible to identify the specific causative agent[s].) A large number of studies of workers exposed to styrene have evidenced no consistent excess risk of all lymphohematopoietic malignancies, although the most sensitive study suggested an excess risk of leukemia among workers with a high exposure. Chapman and Hall, 1997 Malignant neoplasms nationallicence organic solvents nationallicence Lynge Elsebeth Danish Cancer Society, København, Denmark aut Anttila Ahti Finnish Institute of Occupational Health, Helsinki, Finland aut Hemminki Kari Center for Nutrition and Toxicology, Karolinska Institute, Huddinge, Sweden aut Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 406-419 0957-5243 8:3<406 1997 8 10552 https://doi.org/10.1023/A:1018461406120 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018461406120 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lynge Elsebeth Danish Cancer Society, København, Denmark aut NATIONALLICENCE 700 1- Anttila Ahti Finnish Institute of Occupational Health, Helsinki, Finland aut NATIONALLICENCE 700 1- Hemminki Kari Center for Nutrition and Toxicology, Karolinska Institute, Huddinge, Sweden aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/3(1997-05-01), 406-419 0957-5243 8:3<406 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer