caa a22 4500 477129137 CHVBK 20180405111658.0 cr unu---uuuuu 170330e19970701xx s 000 0 eng 10.1023/A:1018438228410 doi (NATIONALLICENCE)springer-10.1023/A:1018438228410 Physical activity and risk of colon cancer: the Physicians‘ Health Study (United States) [Elektronische Daten] [I-Min Lee, JoAnn Manson, Umed Ajani, Ralph Paffenbarger, Charles Hennekens, Julie Buring] Previous studies indicate that physical activity is related inverselyto colon cancer risk. However, details regarding that association - whether adose-response relation exists, whether the relation differs between non-obeseand obese persons, the effect of long-term physical activity - are unclear.We examined these issues in the Physicians‘ Health Study (United States).Physical activity was assessed at baseline among 21,807 men, aged 40 to 84years, and again 36 months later. Men were followed for an average of 10.9years (from baseline) during which 217 developed colon cancer. Afteradjusting for potential confounders (including age, obesity, and alcoholintake), the relative risks for colon cancer associated with vigorousexercise in times per week (< 1, 1, 2-4, 5+, at baseline) were 1.0(referent); 1.1 (95% confidence interval [CI] = 0.7-1.7); 1.2 (CI = 0.8-1.6);and 1.1 (CI = 0.7-1.6), respectively; P trend = 0.6. Physical activity wasnot associated significantly with colon cancer risk either among non-obese orobese men. When we used physical activity assessments at baseline as well asat 36 months, physical activity again was unrelated to colon cancer risk.These data do not support the hypothesis that physical activity reduces therisk of colon cancer. Plausible alternate explanations for the null findinginclude misclassification of physical activity and the potential forincreased surveillance for colon cancer (‘screening effect') among thosephysically active. Chapman and Hall, 1997 Colon cancer nationallicence men nationallicence physical activity nationallicence United States nationallicence Lee I-Min Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut Manson JoAnn Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut Ajani Umed Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut Paffenbarger Ralph Department of Epidemiology, Harvard School of Public Health, Boston, USA aut Hennekens Charles Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut Buring Julie Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/4(1997-07-01), 568-574 0957-5243 8:4<568 1997 8 10552 https://doi.org/10.1023/A:1018438228410 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018438228410 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee I-Min Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Manson JoAnn Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Ajani Umed Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Paffenbarger Ralph Department of Epidemiology, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Hennekens Charles Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Buring Julie Division of Preventive Medicine, Department of Medicine, Brigham and Women‘s Hospital and Harvard Medical School, Boston, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/4(1997-07-01), 568-574 0957-5243 8:4<568 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer