caa a22 4500 477129188 CHVBK 20180405111659.0 cr unu---uuuuu 170330e19970701xx s 000 0 eng 10.1023/A:1018406716115 doi (NATIONALLICENCE)springer-10.1023/A:1018406716115 A case-control study of diet and colorectal cancer in a multiethnic population in Hawaii (United States): lipids and foods of animal origin [Elektronische Daten] [Loïc Le Marchand, Lynne Wilkens, Jean Hankin, Laurence Kolonel, Li-Ching Lyu] Temporal trend and migrant studies have indicated that the etiologyof colorectal cancer is predominantly environmental and, hence, modifiable.Animal fat intake has been frequently, but inconsistently, associated withthe risk of this disease. We conducted a population-based case-control studyin Hawaii (United States) among ethnic groups at different risks of thedisease to evaluate the role of dietary lipids and foods of animal origin onthe risk of colorectal cancer. We interviewed 698 male and 494 femaleJapanese, Caucasian (White), Filipino, Hawaiian, and Chinese patientsdiagnosed during 1987-91 with pathologically confirmed adenocarcinoma of thecolon or rectum, and 1,192 population controls matched to cases on age,gender and ethnicity. Odds ratios (OR), adjusted for caloric intake and otherdietary and non-dietary risk factors, were estimated using conditionallogistic regression. Intakes of total fat, saturated fat (S) andpolyunsaturated fat (P) were not related to the risk of colorectal cancer.However, an inverse association was found for the P/S ratio, with ORs of 0.6in both genders (95 percent confidence interval [CI] = 0.4-1.0 for males; CI= 0.3-0.9 for females) for the highest compared with the lowest quartile (P≤ 0.05 for trend). Intakes of red meat and processed meat were associatedwith the risk of cancer in the right colon and rectum, respectively, in menonly. Fat-trimmed red meat and fish intakes were not related to risk. Chickeneaten without skin was associated inversely with risk in both genders. Thestrongest association was found for eggs, with an OR of 2.7 (CI = 1.7-4.0)and 2.3 (CI = 1.4-3.7) for the highest compared with the lowest quartile ofintake in men and women, respectively (P < 0.001 for trend). This associationwas dose-dependent, not explained by known confounders or other dietaryvariables, and was very consistent between genders, among ethnic groups, andacross all segments of the large bowel. These data sugg est that the ratio ofpolyunsaturated to saturated fat may be a better indicator of colorectalcancer risk than the absolute amount of specific fats in the diet. They alsosuggest that eggs and, possibly, untrimmed red meat and processed meatincrease, and chicken eaten without skin decreases, colorectal cancer risk. Chapman and Hall, 1997 Cholesterol nationallicence colorectal cancer nationallicence diet nationallicence eggs nationallicence ethnic groups nationallicence fat nationallicence lipids nationallicence meat nationallicence United States nationallicence Le Marchand Loïc Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut Wilkens Lynne Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut Hankin Jean Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut Kolonel Laurence Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut Lyu Li-Ching Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/4(1997-07-01), 637-648 0957-5243 8:4<637 1997 8 10552 https://doi.org/10.1023/A:1018406716115 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018406716115 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Le Marchand Loïc Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut NATIONALLICENCE 700 1- Wilkens Lynne Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut NATIONALLICENCE 700 1- Hankin Jean Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut NATIONALLICENCE 700 1- Kolonel Laurence Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut NATIONALLICENCE 700 1- Lyu Li-Ching Cancer Research Center of Hawaii, University of Hawaii, Honolulu, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/4(1997-07-01), 637-648 0957-5243 8:4<637 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer