caa a22 4500 477129196 CHVBK 20180405111659.0 cr unu---uuuuu 170330e19970701xx s 000 0 eng 10.1023/A:1018486111572 doi (NATIONALLICENCE)springer-10.1023/A:1018486111572 Trends in urinary bladder cancer incidence in Sweden 1960-93 with special reference to histopathology, time period, birth cohort, and smoking [Elektronische Daten] [Magnus Thörn, Reinhold Bergström, Anna-Maria Johansson, Lars Ramström, Ingemar Persson, Per-Uno Malmström] This study investigates the incidence trends of urinary bladdercancer in Sweden from 1960 through 1993 (a total of 46,211 cases).Age-standardized incidence rates increased among men from 14.6 per 10 5 in1960 to 33.5 in 1993 and among women from4.8 to 8.8, corresponding to anaverage annual increase of 2.4 percent (95 percent confidence interval [CI])= 2.0-2.7 percent) and 1.1 percent (CI = 0.9-1.4 percent), respectively. Thelargest increase occurred in the oldest age-groups. The proportion ofpatients with transitional cell carcinoma increased in menfrom66.0 percent in1960-64 to 93.6 percent in 1990-93 and in women from 61.0 percent to 89.4percent. The proportion of patients with papillomas decreased, whereas thosewith adenocarcinoma and squamous cell carcinoma were stable. Regressionmodeling (based on the period 1960-89) showed a strong linear effect due toeither period and/or cohort. Among men, additional non-linear effects by bothperiod and cohort were obtained. T he cohort effects were more important.Cohort data on having smoked daily showed considerable similarities with theestimated cohort-effects. Our findings suggest that the increase of tobaccosmoking in successive generations can explain the increase in incidence ratesof bladder cancer in Sweden, whereas improved diagnostic activities andregistration are less likely to explain fully the changes in incidence rates. Chapman and Hall, 1997 Age factors nationallicence bladder cancer nationallicence cohort effect nationallicence smoking nationallicence Sweden nationallicence Thörn Magnus Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut Bergström Reinhold Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut Johansson Anna-Maria Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut Ramström Lars Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut Persson Ingemar Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut Malmström Per-Uno Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut Cancer Causes & Control Kluwer Academic Publishers 8/4(1997-07-01), 560-567 0957-5243 8:4<560 1997 8 10552 https://doi.org/10.1023/A:1018486111572 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018486111572 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thörn Magnus Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 700 1- Bergström Reinhold Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 700 1- Johansson Anna-Maria Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 700 1- Ramström Lars Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 700 1- Persson Ingemar Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 700 1- Malmström Per-Uno Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/4(1997-07-01), 560-567 0957-5243 8:4<560 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer