caa a22 4500 47712920X CHVBK 20180405111659.0 cr unu---uuuuu 170330e19970701xx s 000 0 eng 10.1023/A:1018481910663 doi (NATIONALLICENCE)springer-10.1023/A:1018481910663 A case-control study of cytochrome P450 1A1, glutathione S-transferase M1, cigarette smoking and lung cancer susceptibility (Massachusetts, United States) [Elektronische Daten] [Montserrat García-Closas, Karl Kelsey, John Wiencke, Xiping Xu, John Wain, David Christiani] Cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1)genetic polymorphisms are involved in the activation and detoxification ofchemical carcinogens found in tobacco smoke; thus they may influence hostsusceptibility to lung cancer. In this study at Massachusetts GeneralHospital (Boston, MA, USA) of 416 cases and 446 controls (mostly White) weevaluated the association between the CYP1A1 MspI and GSTM1 polymorphisms andlung cancer risk, and their interaction with cigarette smoke. The CYP1A1 MspIheterozygous genotype was present in 18 percent of cases and 16 percent ofcontrols, and one percent of cases and controls were CYP1A1 MspI homozygousvariant. The GSTM1 null genotype was detected in 54 percent of cases and 52percent of controls. After adjusting for age, gender, pack-years of smoking,and years since quitting smoking, while neither the CYP1A1 MspI heterozygousgenotype alone nor the GSTM1 null genotype alone were associated with asignificant increas e in lung cancer risk, having both genetic traits wasassociated with a twofold increase in risk (95 percent confidence interval[CI] = 1.0-3.4). Our data did not provide enough evidence for a substantialmodification of the effect of pack-years on lung cancer risk by the CYP1A1MspI and GSTM1 genotypes. However, limitations of our study preclude aconclusion about this potential interaction. Chapman and Hall, 1997 Cytochrome P450 nationallicence genotype nationallicence glutathione transferases nationallicence lung neoplasm nationallicence smoking nationallicence United States nationallicence García-Closas Montserrat Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Kelsey Karl Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, USA aut Wiencke John Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, USA aut Xu Xiping Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, USA aut Wain John Thoracic Surgery Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut Christiani David Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/4(1997-07-01), 544-553 0957-5243 8:4<544 1997 8 10552 https://doi.org/10.1023/A:1018481910663 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018481910663 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- García-Closas Montserrat Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Kelsey Karl Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Wiencke John Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, USA aut NATIONALLICENCE 700 1- Xu Xiping Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Wain John Thoracic Surgery Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Christiani David Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/4(1997-07-01), 544-553 0957-5243 8:4<544 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer