caa a22 4500 477129285 CHVBK 20180405111700.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1023/A:1018435522475 doi (NATIONALLICENCE)springer-10.1023/A:1018435522475 International incidence rates of invasive cervical cancer after introduction of cytological screening [Elektronische Daten] [L. Gustafsson, J. Pontén, M. Zack, H.-O. Adami] Because Pap-smear screening can detect pre-invasive cervical cancer,such screening can markedly reduce the occurrence of invasive cancer.However, its impact in different populations is uncertain. This studycompares the changes in cervical cancer incidence at different ages after theintroduction of screening in different populations, and addresses the impactof organized and opportunistic smear taking. We identified 17 cancerregistries large enough and existing long enough to analyze screeningeffects. For each registry, we calculated the relative reduction inage-specific incidence rates and in incidence rates age-standardized to theworld population after the introduction of cytologic screening. In 11 of the17 populations, age-standardized incidence rates declined markedly from 27percent in Norway and to 77 percent in Finland. Age-specific declines wereconfined to women aged 30 to 70 years old with a nadir around ages 40 to 55.In six other populations, age-standardize d incidence rates declined lessthan 25 percent, an amount too small to provide unambiguous evidence of ascreening effect. In several populations, cytologic screening had a morepronounced effect than is generally recognized. Because age-specific declinesin cervical cancer incidence rates were strikingly similar in populationswith widely different screening practices, organized screening may not bemarkedly superior to opportunistic screening. The reduction in reportedcancer incidence because of screening is smaller in younger and older women. Chapman and Hall, 1997 Cervical cancer nationallicence incidence nationallicence screening nationallicence World health nationallicence Gustafsson L. Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut Pontén J. Department of Pathology, University Hospital, Uppsala, Sweden aut Zack M. Division of Chronic Disease Control and Community Intervention, Centers for Disease Control and Prevention, Atlanta, USA aut Adami H.-O Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 755-763 0957-5243 8:5<755 1997 8 10552 https://doi.org/10.1023/A:1018435522475 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018435522475 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gustafsson L. Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 700 1- Pontén J. Department of Pathology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 700 1- Zack M. Division of Chronic Disease Control and Community Intervention, Centers for Disease Control and Prevention, Atlanta, USA aut NATIONALLICENCE 700 1- Adami H.-O Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 755-763 0957-5243 8:5<755 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer