caa a22 4500 477129323 CHVBK 20180405111700.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1023/A:1018479304728 doi (NATIONALLICENCE)springer-10.1023/A:1018479304728 Tobacco, alcohol use, and risks of laryngeal and lung cancer by subsite and histologic type in Turkey [Elektronische Daten] [M. Dosemeci, I. Gokmen, M. Unsal, R. Hayes, A. Blair] Effects of tobacco smoking and alcohol use on risks of cancers of thelarynx and lung have been evaluated extensively in industrialized countries.Few studies on the effect of these risk factors have been reported fromdeveloping countries. We conducted a case-control study to evaluate risks oflaryngeal and lung cancers in men by subsite and cell type in relation tosmoking and alcohol drinking in Turkey, a country where smoking and alcoholconsumption patterns are different from those in industrialized countries. Weidentified 832 laryngeal and 1,210 lung cancer cases and 829 controls withinformation on smoking and alcohol use (amount and duration) and histologiccell type from an oncology treatment center of a Social Security Agencyhospital in Istanbul, Turkey, admitted between 1979 and 1984. Both laryngealand lung cancer showed significant associations with smoking and alcoholdrinking, but no monotonic dose-response was obtained for alcohol drinking.Among smokers, the highest risks were observed in the supraglottis region ofthe larynx (odds ratio [OR] = 4.1) after adjustment for age and alcohol use.Among alcohol drinkers, the highest risks were observed in the glottis regionof the larynx (OR = 1.7) after adjustment for age and smoking. In theanalysis by the cell type of lung cancer among ever-smokers, small cell typeshowed the highest risk (OR = 5.4), while it showed no association withalcohol drinking. Cumulative cigarette use (pack-years) and number ofcigarettes per day showed stronger associations than years smoked for bothcancer sites. The relative risks of joint exposure to smoking and alcoholwere 12.2 for laryngeal cancer and 14.1 for lung cancer among heavy smokersand heavy alcohol drinkers. This study provides epidemiologic evidence fromTurkey that smoking and alcohol use are associated with risks of cancers ofthe larynx and lung. Chapman and Hall, 1997 Alcohol nationallicence histologic type nationallicence laryngeal cancer nationallicence lung cancer nationallicence men nationallicence smoking nationallicence Turkey nationallicence Dosemeci M. Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Gokmen I. Department of Chemistry, Faculty of Arts and Sciences, Middle East Technical University, Ankara, Turkey aut Unsal M. Oncological Clinic, Social Security Agency Hospital at Ok Meydani, Istanbul, Turkey aut Hayes R. Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Blair A. Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 729-737 0957-5243 8:5<729 1997 8 10552 https://doi.org/10.1023/A:1018479304728 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018479304728 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dosemeci M. Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Gokmen I. Department of Chemistry, Faculty of Arts and Sciences, Middle East Technical University, Ankara, Turkey aut NATIONALLICENCE 700 1- Unsal M. Oncological Clinic, Social Security Agency Hospital at Ok Meydani, Istanbul, Turkey aut NATIONALLICENCE 700 1- Hayes R. Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Blair A. Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 729-737 0957-5243 8:5<729 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer