caa a22 4500 477129366 CHVBK 20180405111700.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1023/A:1018491607454 doi (NATIONALLICENCE)springer-10.1023/A:1018491607454 Case-control study of colorectal carcinoma in situ and cancer in relation to cigarette smoking and alcohol use (Japan) [Elektronische Daten] [K. Yamada, S. Araki, M. Tamura, I. Sakai, Y. Takahashi, H. Kashihara, S. Kono] Acase-control study was performed in order to examine the relation ofcigarette smoking and alcohol use to colorectal carcinoma in situ and cancer,separately. Study subjects consisted of 129 colorectal carcinoma in situcases, 66 colorectal cancer cases, and 390 controls recruited from healthcheck-up examinees in Tokyo from January 1991 to March 1993. Smoking statusand alcohol habit were ascertained from a self-administered questionnaire.Both cumulative cigarette smoking and current smoking status were associatedsignificantly with an increased risk of carcinoma in situ. A statisticallynonsignificant increase in the risk of colorectal cancer was noted only amongthose with the heaviest exposure category of these measures of smoking. Thecumulative exposure to cigarette smoking within recent 20 years wasassociated significantly with an increased risk of carcinoma in situ, whereassmoking until 20 years before the diagnosis was associated significantly withan increase of c ancer risk. A significant and positive association wasobserved between cumulative alcohol drinking and colorectal cancer. Thesefindings suggest that cigarette smoking may act as an initiator in colorectalcarcinogenesis and also provide weak evidence that alcohol drinking isrelated to an increased risk of colorectal cancer. Chapman and Hall, 1997 Alcohol nationallicence carcinoma in situ nationallicence colorectal adenomas nationallicence colorectal cancer nationallicence smoking nationallicence Yamada K. PL Tokyo Health Care Center, Tokyo, Japan aut Araki S. Department of Public Health, Tokyo University School of Medicine, Tokyo, Japan aut Tamura M. PL Tokyo Health Care Center, Tokyo, Japan aut Sakai I. PL Tokyo Health Care Center, Tokyo, Japan aut Takahashi Y. PL Tokyo Health Care Center, Tokyo, Japan aut Kashihara H. PL Tokyo Health Care Center, Tokyo, Japan aut Kono S. Department of Public Health, Kyushu University School of Medicine, Fukuoka, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 780-785 0957-5243 8:5<780 1997 8 10552 https://doi.org/10.1023/A:1018491607454 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018491607454 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamada K. PL Tokyo Health Care Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Araki S. Department of Public Health, Tokyo University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Tamura M. PL Tokyo Health Care Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakai I. PL Tokyo Health Care Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Takahashi Y. PL Tokyo Health Care Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Kashihara H. PL Tokyo Health Care Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Kono S. Department of Public Health, Kyushu University School of Medicine, Fukuoka, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 780-785 0957-5243 8:5<780 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer