caa a22 4500 477129374 CHVBK 20180405111700.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1023/A:1018431421567 doi (NATIONALLICENCE)springer-10.1023/A:1018431421567 Bladder cancer and drinking water: a population-based case-control study in Washington County, Maryland (United States) [Elektronische Daten] [D. Freedman, K. Cantor, N. Lee, L.-S. Chen, H.-H. Lei, C. Ruhl, S. Wang] A population-based case-control study was conducted in WashingtonCounty, Maryland (United States) to explore the association between incidentbladder cancer and exposure to drinking water from chlorinated surfacesources. Cancer cases were White residents, enumerated in a 1975 countycensus and reported to the Washington County Cancer Registry (n = 294)between 1975 and 1992. White controls, frequency matched by age (± 5 years)and gender, were selected randomly from the census (n = 2,326). Householdsreceiving municipal water, which generally derived from chlorinated surfacewaters, were treated as having ‘high exposure‘ and all others, as ‘lowexposure.' Duration of exposure to type of drinking water was based on lengthof residence in the census household prior to 1975. Odds ratios (OR) werecalculated using logistic regression methods, adjusting for age, gender,tobacco use, and urbanicity. Bladder cancer risk was associated weakly in thegeneral population with duration o f exposure to municipal water. Theassociation was limited to those who had smoked cigarettes. In ever-smokerscompared with never-smokers with low exposure, the adjusted ORs for bladdercancer risk with increasing exposure were 1.3, 1.4, 1.4, 1.7, 2.2, 2.8,respectively, for 0, 1-10, 11-20, 21-30, 31-40, > 40 years' exposureduration. The ORs in smokers were not diminished after adjusting for smokinghistory and intensity. Chapman and Hall, 1997 Bladder cancer nationallicence chlorine nationallicence United States nationallicence water supply nationallicence Freedman D. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Cantor K. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Lee N. Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut Chen L.-S Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut Lei H.-H Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut Ruhl C. Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut Wang S. Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 738-744 0957-5243 8:5<738 1997 8 10552 https://doi.org/10.1023/A:1018431421567 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018431421567 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Freedman D. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Cantor K. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Lee N. Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut NATIONALLICENCE 700 1- Chen L.-S Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut NATIONALLICENCE 700 1- Lei H.-H Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut NATIONALLICENCE 700 1- Ruhl C. Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut NATIONALLICENCE 700 1- Wang S. Johns Hopkins School of Hygiene and Public Health, Baltimore, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 738-744 0957-5243 8:5<738 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer