caa a22 4500 477129420 CHVBK 20180405111700.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1023/A:1018495708363 doi (NATIONALLICENCE)springer-10.1023/A:1018495708363 Alexander F. Department of Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, UK aut Is Mycoplasma Pneumonia associated with childhood acute lymphoblastic leukemia? [Elektronische Daten] [F. Alexander] Acute lymphoblastic leukemia (ALL) in the childhood peak may be arare response to delayed first exposure to one or more common infectiousagent(s). Mycoplasma Pneumonia has the appropriate socioeconomic correlatesand clinical symptoms and the hypothesis that delayed first exposure to itmay contribute to ALL is considered. Counts of positive reports of MPneumonia from disease surveillance data for England and Wales (UnitedKingdom) for 1975-92 have been taken as proxies for community burden ofinfection. Variation by months of birth (cohort) and diagnosis (period) ofincidence of ALL in children born and diagnosed 1975-92 are compared withpredictions. When periods were classified by mean M Pneumonia count rate inthe nine preceding months, standardized morbidity ratios (SMR) for thehighest and lowest 20 percent were 108 and 89 (rate ratio [RR] = 1.2, 95percent confidence interval [CI] = 1.1-1.4). SMRs for cohorts with highestand lowest predicted risk (i.e., lowest and hi ghest M Pneumonia count ratearound birth and during infancy) were 110 and 97 (RR = 1.1, CI = 1.0-1.3).The trend for period was most marked in the cohorts with low opportunity forexposure when young. This ecologic analysis provides preliminary support forthe hypothesis. Chapman and Hall, 1997 Childhood acute lymphoblastic leukemia nationallicence delayed exposure nationallicence infectious agents nationallicence mycoplasmas nationallicence super-antigens nationallicence United Kingdom nationallicence Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 803-811 0957-5243 8:5<803 1997 8 10552 https://doi.org/10.1023/A:1018495708363 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018495708363 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Alexander F. Department of Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 803-811 0957-5243 8:5<803 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer