caa a22 4500 477129439 CHVBK 20180405111700.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1023/A:1018443724293 doi (NATIONALLICENCE)springer-10.1023/A:1018443724293 Vitamin supplements and cancer risk: the epidemiologic evidence [Elektronische Daten] [R. Patterson, E. White, A. Kristal, M. Neuhouser, J. Potter] This report reviews published epidemiologic research on theassociations of vitamin and mineral supplementation with cancer risk.Although the literature on nutrition and cancer is vast, few reports to datehave addressed supplemental nutrients directly (seven clinical trials, 16cohort, and 36 case-control studies). These studies offer insight intoeffects of nutrients that are distinguishable from effects of otherbiologically active compounds in foods. Randomized clinical trials have notshown significant protective effects of β-carotene, but have foundprotective effects of: α-tocopherol against prostate cancer; mixturesof retinol/zinc and β-carotene/α-tocopherol/ selenium againststomach cancer; and selenium against total, lung, and prostate cancers.Cohort studies provide little evidence that vitamin supplements areassociated with cancer. Case-control studies have reported an inverseassociation between bladder cancer and vitamin C; oral/pharyngeal cancer andseveral supplemental vitamins; and several cancers and vitamin E. Arandomized clinical trial, a cohort study, and a case-control study have allfound inverse associations between colon cancer and vitamin E. Overall, thereis modest evidence for protective effects of nutrients from supplementsagainst several cancers. Future studies of supplement use and cancer appearwarranted; however, methodologic problems that impair ability to assesssupplement use and statistical modeling of the relation between cancer riskand supplement use need attention. Chapman and Hall, 1997 Cancer nationallicence nutrients nationallicence risk factors nationallicence supplements nationallicence vitamins nationallicence Patterson R. Fred Hutchinson Cancer Research Center, Seattle, USA aut White E. Fred Hutchinson Cancer Research Center, Seattle, USA aut Kristal A. Fred Hutchinson Cancer Research Center, Seattle, USA aut Neuhouser M. Fred Hutchinson Cancer Research Center, Seattle, USA aut Potter J. Fred Hutchinson Cancer Research Center, Seattle, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 786-802 0957-5243 8:5<786 1997 8 10552 https://doi.org/10.1023/A:1018443724293 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018443724293 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Patterson R. Fred Hutchinson Cancer Research Center, Seattle, USA aut NATIONALLICENCE 700 1- White E. Fred Hutchinson Cancer Research Center, Seattle, USA aut NATIONALLICENCE 700 1- Kristal A. Fred Hutchinson Cancer Research Center, Seattle, USA aut NATIONALLICENCE 700 1- Neuhouser M. Fred Hutchinson Cancer Research Center, Seattle, USA aut NATIONALLICENCE 700 1- Potter J. Fred Hutchinson Cancer Research Center, Seattle, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/5(1997-09-01), 786-802 0957-5243 8:5<786 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer