caa a22 4500 47712948X CHVBK 20180405111700.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1018459911147 doi (NATIONALLICENCE)springer-10.1023/A:1018459911147 Hormone replacement therapy, reproductive history, and colon cancer: a multicenter, case-control study in the United States [Elektronische Daten] [Ellen Kampman, John Potter, Martha Slattery, Bette Caan, Sandra Edwards] Hormonal factors have been inconsistently associated with coloncancer risk in women. The associations between reproductive events, menstrualfactors, exogenous hormones, and colon cancer were evaluated in a largecase-control study (894 female cases and 1,120 female age-matchedpopulation-based controls) in the United States, stratifying by age atdiagnosis, tumor site, family history and other potential risk factors.Overall, higher parity was associated with a marginally decreased risk ofcolon cancer (five or more births compared with nulliparous: odds ratio [OR]= 0.75, 95 percent confidence interval [CI] = 0.53-1.06) after adjusting forage at diagnosis, family history of colorectal cancer, vigorous lifetimephysical activity, body mass index (BMI) (wt/ht 1.5 ), total energy intake,and aspirin use. No important associations were observed for otherreproductive or menstrual events. An inverse association between recent useof hormone replacement therapy (HRT) and colon cancer was observed (OR = 0.71, CI = 0.56-0.89). Although interaction termswere not significant, this inverse association appeared to be more pronouncedfor those with an older age at diagnosis; for those without a first-degreerelative with colorectal cancer; and for those with a relatively low BMI. Thereduced risk associated with HRT use did not appear to be explained by otherbehaviors related to HRT use. Chapman and Hall, 1997 Colon cancer nationallicence hormone replacement therapy nationallicence reproductive history nationallicence risk factors nationallicence United States nationallicence women nationallicence Kampman Ellen Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, USA aut Potter John Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, USA aut Slattery Martha University of Utah, Salt Lake City, USA aut Caan Bette Kaiser Permanente Medical Research Program, Oakland, USA aut Edwards Sandra University of Utah, Salt Lake City, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 146-158 0957-5243 8:2<146 1997 8 10552 https://doi.org/10.1023/A:1018459911147 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018459911147 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kampman Ellen Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, USA aut NATIONALLICENCE 700 1- Potter John Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, USA aut NATIONALLICENCE 700 1- Slattery Martha University of Utah, Salt Lake City, USA aut NATIONALLICENCE 700 1- Caan Bette Kaiser Permanente Medical Research Program, Oakland, USA aut NATIONALLICENCE 700 1- Edwards Sandra University of Utah, Salt Lake City, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 146-158 0957-5243 8:2<146 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer