caa a22 4500 477129528 CHVBK 20180405111700.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1018416128894 doi (NATIONALLICENCE)springer-10.1023/A:1018416128894 Meat preparation and colorectal adenomas in a large sigmoidoscopy-based case-control study in California (United States) [Elektronische Daten] [Nicole Probst-Hensch, Rashmi Sinha, Matthew Longnecker, John Witte, Sue Ingles, Harold Frankl, Eric Lee, Robert Haile] The often observed association between red meat and colorectal cancercould be due in part to mutagens, such as heterocyclic amines (HCA), that arepresent in cooked meat. HCAs are highly mutagenic and cause intestinal tumorsin animals. The hypothesis that HCAs are also carcinogenic to humans remainsto be substantiated in epidemiologic studies. We determined the associationsof meat preparation and frequency of intake (proxy variables for HCAexposure, since HCA concentration depends on the type of meat and the way itis cooked) with the prevalence of distal colorectal adenomas in asigmoidoscopy-based case-control study of 488 matched pairs of subjects fromtwo California (United States) Kaiser Permanente Medical Centers. A more thantwofold difference in adenoma prevalence between subjects at extreme ends ofestimated HCA intake was observed. For subjects who ate red meat more thanonce per week, fried it more than 10 percent of the time, and ate it with adarkly browned surface, compared with subjects who ate red meat one time orless per week, fried it 10 or less percent of the time, and ate it with alightly browned surface, the odds ratio was 2.2 (95 percent confidenceinterval = 1.1-4.3). Adenoma prevalence also increased with frequency offrying red meat (P trend = 0.004). These results are consistent with acarcinogenic effect of HCA. Chapman and Hall, 1997 Adenoma nationallicence amines nationallicence colon nationallicence meat-products nationallicence mutagens nationallicence United States nationallicence Probst-Hensch Nicole Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, USA aut Sinha Rashmi Nutritional Epidemiology Section/Epidemiology and Biostatistics Program, National Cancer Institute, NIH, Rockville, USA aut Longnecker Matthew NIEHS Epidemiology Branch Research, Triangle Park, USA aut Witte John Department of Epidemiology and Biostatistics, Case Western Reserve, University School of Medicine, Cleveland, USA aut Ingles Sue Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, USA aut Frankl Harold Department of Gastroenterology, Kaiser Permanente, Los Angeles, USA aut Lee Eric Bellflower, CA, USA aut Haile Robert Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 175-183 0957-5243 8:2<175 1997 8 10552 https://doi.org/10.1023/A:1018416128894 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018416128894 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Probst-Hensch Nicole Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, USA aut NATIONALLICENCE 700 1- Sinha Rashmi Nutritional Epidemiology Section/Epidemiology and Biostatistics Program, National Cancer Institute, NIH, Rockville, USA aut NATIONALLICENCE 700 1- Longnecker Matthew NIEHS Epidemiology Branch Research, Triangle Park, USA aut NATIONALLICENCE 700 1- Witte John Department of Epidemiology and Biostatistics, Case Western Reserve, University School of Medicine, Cleveland, USA aut NATIONALLICENCE 700 1- Ingles Sue Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, USA aut NATIONALLICENCE 700 1- Frankl Harold Department of Gastroenterology, Kaiser Permanente, Los Angeles, USA aut NATIONALLICENCE 700 1- Lee Eric Bellflower, CA, USA aut NATIONALLICENCE 700 1- Haile Robert Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 175-183 0957-5243 8:2<175 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer