caa a22 4500 477129552 CHVBK 20180405111700.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1018472213872 doi (NATIONALLICENCE)springer-10.1023/A:1018472213872 Elevated incidence of hematologic malignancies in patients with Sjögren's syndrome compared with patients with rheumatoid arthritis (Finland) [Elektronische Daten] [Markku Kauppi, Eero Pukkala, Heikki Isomäki] The risk of hematologic malignancies was studied in Finnish patients withrheumatoid arthritis or Sjögren's syndrome, and the difference in the riskbetween those diseases was evaluated. The study cohorts comprised 676patients with primary Sjögren's syndrome, 709 with secondary Sjögren'ssyndrome, and 9,469 with rheumatoid arthritis identified from the Finnishhospitals' national discharge register. The follow-up times were 5,336, 4,254and 65,391 person-years, respectively. Data on the incidence of malignancieswere collected from the files of the Finnish Cancer Registry. The incidenceof hematologic malignancies was elevated in the study cohorts. Thestandardized incidence ratio (SIR) of non-Hodgkin's lymphoma was: 2.2 (95percent confidence interval [CI] 1.5-3.1) for rheumatoid arthritis; 4.5 (CI =1.5-11) for secondary Sjögren's syndrome; and 8.7 (CI = 4.3-16) for primarySjögren's syndrome. The ratio of the SIR of primary Sjögren's syndroma cfrheumatoid arthritis alone was 3.9 (CI = 1.8-8.0) in non-Hodgkin's lymphoma,and 3.4 (CI = 1.2-8.1) in other hematologic cancers. The incidence ofhematologic malignancies, especially that of non-Hodgkin's lymphoma, iselevated in patients with rheumatoid arthritis. It is higher in patients withsecondary Sjögren's syndrome and highest in patients with primary Sjögren'ssyndrome. Differences in the immuno-logic aberration influenceoncogenesis. Chapman and Hall, 1997 Finland nationallicence lymphoma nationallicence Sjögren's syndrome nationallicence rheumatoid arthritis nationallicence Kauppi Markku Rheumatism Foundation Hospital, Heinola, Finland aut Pukkala Eero Finnish Cancer Registry, Finland aut Isomäki Heikki University of Tampere, Tampere, Finland aut Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 201-204 0957-5243 8:2<201 1997 8 10552 https://doi.org/10.1023/A:1018472213872 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018472213872 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kauppi Markku Rheumatism Foundation Hospital, Heinola, Finland aut NATIONALLICENCE 700 1- Pukkala Eero Finnish Cancer Registry, Finland aut NATIONALLICENCE 700 1- Isomäki Heikki University of Tampere, Tampere, Finland aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 201-204 0957-5243 8:2<201 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer