caa a22 4500 477129587 CHVBK 20180405111701.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1018480515690 doi (NATIONALLICENCE)springer-10.1023/A:1018480515690 Aggregation of childhood leukemia in geographic areas of Greece) [Elektronische Daten] [Eleni Petridou, Freda Alexander, Dimitrios Trichopoulos, Katharine Revinthi, Nick Dessypris, Naomi Wray, Stavros Haidas, Dimitrios Koliouskas, Helen Kosmidis, Fani Piperopoulou, Fotini Tzortzatou] A total of 872 children aged up to 14 years, who were diagnosed withleukemia in Greece during the decade 1980-89, were allocated by place ofresidence to the 601 administrative districts of the country. Evaluation ofspatial clustering was done using the Potthoff-Whittinghill method, whichvalidly assesses heterogeneity of leukemia risk among districts with variableexpected numbers of cases. There was highly significant evidence for spatialclustering occurring particularly among children living in urban and, to alesser extent, semi-urban areas. The evidence was stronger for childrenyounger than 10 years old, applied also to children in different five-yearage groups, and persisted when cases of acute lymphoblastic leukemia wereanalyzed separately. These findings provide support to the hypothesis thatlocalized environmental exposures could contribute to the etiology ofchildhood leukemia, but they cannot distinguish between exposures of physicalor chemical nature, nor can they exclude socially conditioned patterns ofexposure to infectious agents. Chapman and Hall, 1997 Childhood leukemia nationallicence environmental exposure nationallicence Greece nationallicence spatial clustering nationallicence Petridou Eleni Dept. of Epidemiology, Harvard School of Public Health, Boston, USA aut Alexander Freda Dept. of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, UK aut Trichopoulos Dimitrios Dept. of Epidemiology, Harvard School of Public Health, Boston, USA aut Revinthi Katharine Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece aut Dessypris Nick Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece aut Wray Naomi Dept. of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, UK aut Haidas Stavros Dept. of Pediatric Hematology-Oncology, Ag. Sophia Children's Hospital, Athens, Greece aut Koliouskas Dimitrios Dept. of Pediatric Hematology-Oncology, Ippocrateion General Hospital, Salonica, Greece aut Kosmidis Helen Dept. of Pediatric Hematology-Oncology, A. Kyriakou Children's Hospital, Athens, Greece aut Piperopoulou Fani Second Dept. of Pediatrics, Aristoteleion University of Salonica AHEPA General Hospital, Salonica, Greece aut Tzortzatou Fotini First Dept. of Pediatrics, Athens University Medical School Ag. Sophia Children's Hospital, Athens, Greece aut Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 239-245 0957-5243 8:2<239 1997 8 10552 https://doi.org/10.1023/A:1018480515690 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018480515690 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Petridou Eleni Dept. of Epidemiology, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Alexander Freda Dept. of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, UK aut NATIONALLICENCE 700 1- Trichopoulos Dimitrios Dept. of Epidemiology, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Revinthi Katharine Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Dessypris Nick Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Wray Naomi Dept. of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, UK aut NATIONALLICENCE 700 1- Haidas Stavros Dept. of Pediatric Hematology-Oncology, Ag. Sophia Children's Hospital, Athens, Greece aut NATIONALLICENCE 700 1- Koliouskas Dimitrios Dept. of Pediatric Hematology-Oncology, Ippocrateion General Hospital, Salonica, Greece aut NATIONALLICENCE 700 1- Kosmidis Helen Dept. of Pediatric Hematology-Oncology, A. Kyriakou Children's Hospital, Athens, Greece aut NATIONALLICENCE 700 1- Piperopoulou Fani Second Dept. of Pediatrics, Aristoteleion University of Salonica AHEPA General Hospital, Salonica, Greece aut NATIONALLICENCE 700 1- Tzortzatou Fotini First Dept. of Pediatrics, Athens University Medical School Ag. Sophia Children's Hospital, Athens, Greece aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 239-245 0957-5243 8:2<239 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer