caa a22 4500 477129617 CHVBK 20180405111701.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1018476414781 doi (NATIONALLICENCE)springer-10.1023/A:1018476414781 The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case-control studies [Elektronische Daten] [Geoffrey Howe, Kristan Aronson, Enrique Benito, Roberto Castelleto, Jacqueline Cornée, Stephen Duffy, Richard Gallagher, José Iscovich, Jiao Deng-ao, Rudolf Kaaks, Gabriel Kune, Susan Kune, Hin Lee, Marion Lee, Anthony Miller, Ruth Peters, John Potter, Elio Riboli, Martha Slattery, Dimitrios Trichopoulos, Albert Tuyns, Anastasia Tzonou, Lyndsey Watson, Alice Whittemore, Anna Wu-Williams, Zheng Shu] The objective of this study was to examine the effects of the intakeof dietary fat upon colorectal cancer risk in a combined analysis of datafrom 13 case-control studies previously conducted in populations withdiffering colorectal cancer rates and dietary practices. Original datarecords for 5,287 cases of colorectal cancer and 10,470 controls werecombined. Logistic regression analysis was used to estimate odds ratios (OR)for intakes of total energy, total fat and its components, and cholesterol.Positive associations with energy intake were observed for 11 of the 13studies. However, there was little, if any, evidence of anyenergy-independent effect of either total fat with ORs of 1.00, 0.95, 1.01,1.02, and 0.92 for quintiles of residuals of total fat intake (P trend =0.67) or for saturated fat with ORs of 1.00, 1.08, 1.06, 1.21, and 1.06 (Ptrend = 0.39). The analysis suggests that, among these case-control studies,there is no energy-independent association between dietary fat intake andrisk of colorectal cancer. It also suggests that simple substitution of fatby other sources of calories is unlikely to reduce meaningfully the risk ofcolorectal cancer. Chapman and Hall, 1997 Case-control studies nationallicence colorectal neoplasms nationallicence dietary fat nationallicence energy nationallicence Howe Geoffrey Division of Epidemiology, Columbia University School of Public Health, New York, USA aut Aronson Kristan Community Health and Epidemiology, Queens University, Kingston, Canada aut Benito Enrique Unitat d'Epidemiologia i Registre de Cancer de Mallorca, Palma de Mallorca, Spain aut Castelleto Roberto Department of Pathology, La Plata National University, La Plata, Argentina aut Cornée Jacqueline INSERM, Lyon, France aut Duffy Stephen Biostatistics Unit, Medical Research Council, Cambridge, UK aut Gallagher Richard Cancer Control Agency of British Columbia, Vancouver, Canada aut Iscovich José Ministry of Health Jerusalem, Israel Center for Registration of Cancer and Allied Diseases, Israel aut Deng-ao Jiao Chejiang Medical University Hangcho, People's Republic of China aut Kaaks Rudolf International Agency for Research on Cancer, Lyon, France aut Kune Gabriel Department of Surgery, University of Melbourne, Melbourne, Australia aut Kune Susan Department of Surgery, University of Melbourne, Melbourne, Australia aut Lee Hin Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore aut Lee Marion Department of Epidemiology and Biostatistics, University of California, San Francisco, USA aut Miller Anthony Department of Preventive Medicine and Biostatistics, University of Toronto, Toronto, Canada aut Peters Ruth Department of Preventive Medicine, University of Southern California, School of Medicine, Los Angeles, USA aut Potter John Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA aut Riboli Elio International Agency for Research on Cancer, Lyon, France aut Slattery Martha Department of Oncological Sciences, University of Utah, Salt Lake City, USA aut Trichopoulos Dimitrios Department of Epidemiology, Harvard School of Public Health, Boston, USA aut Tuyns Albert International Agency for Research on Cancer, Lyon, France aut Tzonou Anastasia Department of Hygiene and Epidemiology, University of Athens, Athens, Greece aut Watson Lyndsey Department of Surgery, University of Melbourne, Melbourne, Australia aut Whittemore Alice Department of Health Research and Policy, Division of Epidemiology, Stanford University, Stanford, USA aut Wu-Williams Anna Department of Preventive Medicine, University of Southern California, School of Medicine, Los Angeles, USA aut Shu Zheng Chejiang Medical University Hangcho, People's Republic of China aut Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 215-228 0957-5243 8:2<215 1997 8 10552 https://doi.org/10.1023/A:1018476414781 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018476414781 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Howe Geoffrey Division of Epidemiology, Columbia University School of Public Health, New York, USA aut NATIONALLICENCE 700 1- Aronson Kristan Community Health and Epidemiology, Queens University, Kingston, Canada aut NATIONALLICENCE 700 1- Benito Enrique Unitat d'Epidemiologia i Registre de Cancer de Mallorca, Palma de Mallorca, Spain aut NATIONALLICENCE 700 1- Castelleto Roberto Department of Pathology, La Plata National University, La Plata, Argentina aut NATIONALLICENCE 700 1- Cornée Jacqueline INSERM, Lyon, France aut NATIONALLICENCE 700 1- Duffy Stephen Biostatistics Unit, Medical Research Council, Cambridge, UK aut NATIONALLICENCE 700 1- Gallagher Richard Cancer Control Agency of British Columbia, Vancouver, Canada aut NATIONALLICENCE 700 1- Iscovich José Ministry of Health Jerusalem, Israel Center for Registration of Cancer and Allied Diseases, Israel aut NATIONALLICENCE 700 1- Deng-ao Jiao Chejiang Medical University Hangcho, People's Republic of China aut NATIONALLICENCE 700 1- Kaaks Rudolf International Agency for Research on Cancer, Lyon, France aut NATIONALLICENCE 700 1- Kune Gabriel Department of Surgery, University of Melbourne, Melbourne, Australia aut NATIONALLICENCE 700 1- Kune Susan Department of Surgery, University of Melbourne, Melbourne, Australia aut NATIONALLICENCE 700 1- Lee Hin Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore aut NATIONALLICENCE 700 1- Lee Marion Department of Epidemiology and Biostatistics, University of California, San Francisco, USA aut NATIONALLICENCE 700 1- Miller Anthony Department of Preventive Medicine and Biostatistics, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Peters Ruth Department of Preventive Medicine, University of Southern California, School of Medicine, Los Angeles, USA aut NATIONALLICENCE 700 1- Potter John Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA aut NATIONALLICENCE 700 1- Riboli Elio International Agency for Research on Cancer, Lyon, France aut NATIONALLICENCE 700 1- Slattery Martha Department of Oncological Sciences, University of Utah, Salt Lake City, USA aut NATIONALLICENCE 700 1- Trichopoulos Dimitrios Department of Epidemiology, Harvard School of Public Health, Boston, USA aut NATIONALLICENCE 700 1- Tuyns Albert International Agency for Research on Cancer, Lyon, France aut NATIONALLICENCE 700 1- Tzonou Anastasia Department of Hygiene and Epidemiology, University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Watson Lyndsey Department of Surgery, University of Melbourne, Melbourne, Australia aut NATIONALLICENCE 700 1- Whittemore Alice Department of Health Research and Policy, Division of Epidemiology, Stanford University, Stanford, USA aut NATIONALLICENCE 700 1- Wu-Williams Anna Department of Preventive Medicine, University of Southern California, School of Medicine, Los Angeles, USA aut NATIONALLICENCE 700 1- Shu Zheng Chejiang Medical University Hangcho, People's Republic of China aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 215-228 0957-5243 8:2<215 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer