caa a22 4500 477129633 CHVBK 20180405111701.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1018455810238 doi (NATIONALLICENCE)springer-10.1023/A:1018455810238 A prospective study of menopausal hormones and risk of colorectal cancer (United States) [Elektronische Daten] [Rebecca Troisi, Catherine Schairer, Wong-Ho Chow, Arthur Schatzkin, Louise Brinton, Joseph Fraumeni] The relation of colorectal cancer and its subsites with use ofmenopausal hormones was evaluated in the United States among 40,464postmenopausal women, 41 to 80 years of age, who initially volunteered for anationwide breast-cancer screening program and were followed for an averageof 7.7 years. Ever-use of menopausal hormones was not associated with risk oftotal colorectal cancers (relative risk [RR] = 0.99, 95 percent confidenceinterval [CI] = 0.79-1.2) or cancers of the colon (RR = 1.1, CI = 0.81-1.6)or rectum (RR = 1.1, CI = 0.59-1.9). Recent hormone users, however, had asmall nonsignificant reduction in risk of colorectal cancer (RR = 0.78, CI =0.55-1.1), which was most pronounced for distal colon (RR = 0.68, CI =0.29-1.6) and rectal tumors (RR = 0.64, CI = 0.24-1.7). No effect wasobserved for former hormone users, and risk generally did not vary by timesince last use, type of regimen, or duration of use. However, the reducedrisk for recent users was stronger for users of five or more years'duration. These data show some lowering of colorectal cancer risk amongrecent menopausal hormone users of long duration. Chapman and Hall, 1997 Colorectal cancer nationallicence hormone replacement therapy nationallicence menopausal estrogens nationallicence United States nationallicence women nationallicence Troisi Rebecca the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Schairer Catherine the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Chow Wong-Ho the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Schatzkin Arthur Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, USA aut Brinton Louise the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Fraumeni Joseph the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 130-138 0957-5243 8:2<130 1997 8 10552 https://doi.org/10.1023/A:1018455810238 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018455810238 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Troisi Rebecca the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Schairer Catherine the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Chow Wong-Ho the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Schatzkin Arthur Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Brinton Louise the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 700 1- Fraumeni Joseph the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Kluwer Academic Publishers 8/2(1997-03-01), 130-138 0957-5243 8:2<130 1997 8 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer