caa a22 4500 477132278 CHVBK 20180405111706.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1023/A:1018314719904 doi (NATIONALLICENCE)springer-10.1023/A:1018314719904 The chirality selectivity in the uptake of platinum (II) complexes with 1,2-cyclohexanediamine isomers as carrier ligand by human erythrocytes [Elektronische Daten] [Juan Zou, Xiao Yang, Rong Li, Jing Lu, Kui Wang] The uptake kinetics of cisplatin analogs of 1,2-cyclohexanediamine(dach) isomers with various leaving groups, by human erythrocytes in plasma isotonic buffer, were studied. The experimental results showed that the uptake rate constants (k values) decrease with the change of leaving group in the sequence: chloride (Cl) > squaric acid (SA) > oxalate (OX) > demethylcantharic acid (DA), with the same dach isomer as carrier group. It is noteworthy that for the platinum (II) complexes with the same leaving group, the k values always reduce as: 1R, 2R-dach > 1R, 2S-dach > 1S, 2S-dach. This result reflects the chirality selectivity. No differences in reactivity to protein thiols and effects on membrane permeability were found for the R,R-, R,S-, S,S-isomeric complexes. It is proposed that the chirality selectivity in uptake is due to the recognition of the chirality of the platinum complexes by the erythrocyte membrane. The interactions between the chiral platinum complexes and the head groups of the membrane phospholipid molecules are probably involved. Chapman and Hall, 1997 chirality nationallicence 1,2-cyclohexanediamine nationallicence human erythrocyte nationallicence platinum complexes nationallicence uptake nationallicence Zou Juan State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University, Nanjing, China aut Yang Xiao Inorganic Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University, Beijing, China aut Li Rong Inorganic Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University, Beijing, China aut Lu Jing Inorganic Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University, Beijing, China aut Wang Kui Inorganic Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University, Beijing, China aut Biometals Kluwer Academic Publishers 10/1(1997-03-01), 37-43 0966-0844 10:1<37 1997 10 10534 https://doi.org/10.1023/A:1018314719904 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018314719904 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zou Juan State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University, Nanjing, China aut NATIONALLICENCE 700 1- Yang Xiao Inorganic Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University, Beijing, China aut NATIONALLICENCE 700 1- Li Rong Inorganic Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University, Beijing, China aut NATIONALLICENCE 700 1- Lu Jing Inorganic Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University, Beijing, China aut NATIONALLICENCE 700 1- Wang Kui Inorganic Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University, Beijing, China aut NATIONALLICENCE 773 0- Biometals Kluwer Academic Publishers 10/1(1997-03-01), 37-43 0966-0844 10:1<37 1997 10 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer