caa a22 4500 477132413 CHVBK 20180405111707.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1023/A:1018399611243 doi (NATIONALLICENCE)springer-10.1023/A:1018399611243 Uptake of 26-Al and 67-Ga into brain and other tissues of normal and hypotransferrinaemic mice [Elektronische Daten] [Aleksandar Radunovic´, Fukiko Ueda, Kishor Raja, Robert Simpson, Jill Templar, Samantha King, John Lilley, J. Philip Day, Michael Bradbury] Aluminium uptake from blood into tissues of control and homozygous hypotransferrinaemic (hpx/hpx) mice, following continuous intravenous infusion of Al and Ga, has been compared with that of gallium, a proposed tracer for aluminium. Al uptake into tissues of control (hpx/+ and +/+) mice occurred in the order (expressed as a space): bone 464.7ml 100g; renal cortex 102.9ml 100g; liver 13.0ml 100g; spleen 8.4ml 100g and brain 0.8ml 100g. Ga uptakes were similar in liver, spleen and brain, but smaller in the renal cortex and bone, at one-third and one-fifth of the values for Al, respectively. In the hypotransferrinaemic mice, uptake of Ga into all tissues was increased, especially in renal cortex (ninefold) and bone (twentyfold) as compared with the controls. Increases in Ga uptakes into cerebral hemisphere, cerebellum and brain stem of the hypotransferrinaemic mice were 3.8, 4.2 and 2.8 fold, respectively. Al uptake into tissues of the hypotransferrinaemic mice was similar to control values except in bone where it was three times greater. Pre-treatment of control animals with the anti-transferrin receptor antibody, RI7 208, enhanced Ga uptake in all tissues, the effect being greatest in renal cortex (tenfold) and bone (ninefold). Ga uptakes into cerebral hemisphere, cerebellum and brain stem in the mice pre-treated with RI7 208 were 6.4, 6 and 10 times greater than in untreated mice, respectively. No influence of antibody on Al uptake into mouse tissues was observed except in spleen where it was three times greater than in untreated mice. Hence, transport of aluminium and gallium into mouse tissues is not similar under all conditions. Non-transferrin mediated transport of each metal can occur into all tissues, especially in renal cortex and bone, where gallium may be a suitable marker for aluminium. Chapman and Hall, 1997 aluminium nationallicence gallium nationallicence hypotransferrinaemia nationallicence transferrin nationallicence transferrin receptor nationallicence Radunovic´ Aleksandar Physiology Group, King's College, London, UK aut Ueda Fukiko Physiology Group, King's College, London, UK aut Raja Kishor Clinical Biochemistry, King's College School of Medicine and Dentistry, London, UK aut Simpson Robert Clinical Biochemistry, King's College School of Medicine and Dentistry, London, UK aut Templar Jill Department of Chemistry, University of Manchester, Manchester, UK aut King Samantha Department of Chemistry, University of Manchester, Manchester, UK aut Lilley John SERC Daresbury Laboratory, Warrington, UK aut Philip Day J. Department of Chemistry, University of Manchester, Manchester, UK aut Bradbury Michael Physiology Group, King's College, London, UK aut Biometals Kluwer Academic Publishers 10/3(1997-09-01), 185-191 0966-0844 10:3<185 1997 10 10534 https://doi.org/10.1023/A:1018399611243 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018399611243 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Radunovic´ Aleksandar Physiology Group, King's College, London, UK aut NATIONALLICENCE 700 1- Ueda Fukiko Physiology Group, King's College, London, UK aut NATIONALLICENCE 700 1- Raja Kishor Clinical Biochemistry, King's College School of Medicine and Dentistry, London, UK aut NATIONALLICENCE 700 1- Simpson Robert Clinical Biochemistry, King's College School of Medicine and Dentistry, London, UK aut NATIONALLICENCE 700 1- Templar Jill Department of Chemistry, University of Manchester, Manchester, UK aut NATIONALLICENCE 700 1- King Samantha Department of Chemistry, University of Manchester, Manchester, UK aut NATIONALLICENCE 700 1- Lilley John SERC Daresbury Laboratory, Warrington, UK aut NATIONALLICENCE 700 1- Philip Day J. Department of Chemistry, University of Manchester, Manchester, UK aut NATIONALLICENCE 700 1- Bradbury Michael Physiology Group, King's College, London, UK aut NATIONALLICENCE 773 0- Biometals Kluwer Academic Publishers 10/3(1997-09-01), 185-191 0966-0844 10:3<185 1997 10 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer