caa a22 4500 477132464 CHVBK 20180405111707.0 cr unu---uuuuu 170330e19971201xx s 000 0 eng 10.1023/A:1018368231716 doi (NATIONALLICENCE)springer-10.1023/A:1018368231716 Effect of nicotinic acid on zinc and iron metabolism [Elektronische Daten] [V. Agte, K. Paknikar, S. Chiplonkar] Nicotinic acid has functional groups capable of forming complexes with trace metals. The present study examines the effect of nicotinic acid supplementation on absorption and utilization of zinc and iron. In vitro zinc uptake by human erythrocytes was studied using blood samples of 10 healthy subjects. It was found that 8 μmoles nicotinic acid or NADP increased 65Zn uptake by 38.9% and 43.1% in fasting, and by 70.9% and 28.1% in postprandial conditions. In animal experiments, nicotinic acid supplementation to finger millet based diet resulted in significant enhancement of percent zinc absorption, liver zinc and growth of weanling mice (P < 0.05). When mice were fed with nicotinic acid-deficient, -adequate and -excess synthetic diets for four weeks it was observed that, in comparison with the nicotinic acid-deficient diet, percent zinc absorption, intestinal zinc, percent haeomoglobin and liver iron increased significantly under nicotinic acid-adequate and -excess conditions. The results obtained suggested that nicotinic acid, in addition to its known effect on growth and metabolism, may be playing an important role in enhancing zinc and iron utilization. Chapman and Hall, 1997 in vitro zinc uptake nationallicence nicotinic acid nationallicence zinc and iron bioavailability nationallicence Agte V. Agharkar Research Institute, Pune, India aut Paknikar K. Agharkar Research Institute, Pune, India aut Chiplonkar S. Agharkar Research Institute, Pune, India aut Biometals Kluwer Academic Publishers 10/4(1997-12-01), 271-276 0966-0844 10:4<271 1997 10 10534 https://doi.org/10.1023/A:1018368231716 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018368231716 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Agte V. Agharkar Research Institute, Pune, India aut NATIONALLICENCE 700 1- Paknikar K. Agharkar Research Institute, Pune, India aut NATIONALLICENCE 700 1- Chiplonkar S. Agharkar Research Institute, Pune, India aut NATIONALLICENCE 773 0- Biometals Kluwer Academic Publishers 10/4(1997-12-01), 271-276 0966-0844 10:4<271 1997 10 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer