caa a22 4500 477132499 CHVBK 20180405111707.0 cr unu---uuuuu 170330e19971201xx s 000 0 eng 10.1023/A:1018372332624 doi (NATIONALLICENCE)springer-10.1023/A:1018372332624 Inorganic mercury binding to fish oocyte plasma membrane induces steroidogenesis and translatable messenger RNA synthesis [Elektronische Daten] [Shawli Mondal, Banibrata Mukhopadhyay, Shelley Bhattacharya] Both in vitro and in vivo HgCl treatment demonstrated a remarkably high rate of progesterone synthesis accompanied by a low rate of conversion to 17β-estradiol in the oocyte of Channa punctatus. On depuration, however, there was a reversal of the steroidogenic scenario with a low progesterone and high estradiol level. The accumulation of progesterone was positively correlated with the significant increase in 3β-hydroxysteroid dehydrogenase activity in the Hg-treated fish. Thus, it was clear that at the early stage of intoxication Hg does play a role in the induction of 3β-hydroxysteroid dehydrogenase in the oocyte of fish at the spawning stage. The induction of this enzyme was found to be mediated by specific binding of Hg to the plasma membrane Na-K-ATPase (B: 14 nmoles mg protein; K 1.14 x 108 moles) and increase in the specific messenger RNA translating 3β-hydroxysteroid dehydrogenase. It is concluded that inorganic mercury is able to initiate translatable messenger RNA synthesis in fish oocyte at a low degree of intoxication. Chapman and Hall, 1997 3β-HSD nationallicence fish oocyte nationallicence mercury nationallicence Na-K-ATPase nationallicence steroidogenesis nationallicence Mondal Shawli Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University, Santiniketan, India aut Mukhopadhyay Banibrata Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University, Santiniketan, India aut Bhattacharya Shelley Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University, Santiniketan, India aut Biometals Kluwer Academic Publishers 10/4(1997-12-01), 285-290 0966-0844 10:4<285 1997 10 10534 https://doi.org/10.1023/A:1018372332624 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018372332624 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mondal Shawli Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University, Santiniketan, India aut NATIONALLICENCE 700 1- Mukhopadhyay Banibrata Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University, Santiniketan, India aut NATIONALLICENCE 700 1- Bhattacharya Shelley Environmental Toxicology Laboratory, Department of Zoology, Visva Bharati University, Santiniketan, India aut NATIONALLICENCE 773 0- Biometals Kluwer Academic Publishers 10/4(1997-12-01), 285-290 0966-0844 10:4<285 1997 10 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer