caa a22 4500 47713257X CHVBK 20180405111707.0 cr unu---uuuuu 170330e19971201xx s 000 0 eng 10.1023/A:1018392904399 doi (NATIONALLICENCE)springer-10.1023/A:1018392904399 Urinary excretion of mercury, copper and zinc in subjects exposed to mercury vapour [Elektronische Daten] [Gerd Sällsten, Lars Barregård] The excretion of mercury, copper and zinc in urine, and mercury in whole blood andplasma, was determined in 40 chloralkali workers exposed to mercury vapour and 40age-matched referents. The Hg concentrations in whole blood, plasma and urine werehigher in the exposed group (35 nmol l, 30 nmol l,and 11.5 nmol mmol creatinine, respectively) in comparison with thereference group (15 nmol l, 6.3 nmol l, and 1.8nmol mmol creatinine, respectively). The urinary copper excretionwas similar in the two groups, while U-Zn excretion was significantly higher (P = 0.04)in the exposed group, median 0.83 mmol mmol creatinine versus 0.76mnmol mmol creatinine in the reference group. In a subgroup of exposedworkers with current U-Hg above 11.5 nmol lmmolcreatinine (20 mg g creatinine) the medianU-Zn was 1.1 mmol mmol creatinine. In both groups smokers had highU-Zn levels than non smokers. When both U-Hg and smoking were taken into account in alinear regression model, there was a significant association between U-Hg and U-Zn inthe combined group of exposed and referents (P = 0.002). This study indicates thatmercury exposure in humans, as in animals, causes increased urinary excretion of zinc.The mechanisms may be induced synthesis of metallothionein in the kidneys, displacementof Zn from preexisting metallothionein by Hg, or a decreased reabsorption of zinc in thekidneys owing to a slight tubular dysfunction. Chapman and Hall, 1997 copper nationallicence exposure nationallicence mercury nationallicence smoking nationallicence zinc nationallicence Sällsten Gerd Department of Occupational Medicine, Sahlgrenska University Hospital, Göteborg, Sweden aut Barregård Lars Department of Occupational Medicine, Sahlgrenska University Hospital, Göteborg, Sweden aut Biometals Kluwer Academic Publishers 10/4(1997-12-01), 357-361 0966-0844 10:4<357 1997 10 10534 https://doi.org/10.1023/A:1018392904399 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018392904399 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sällsten Gerd Department of Occupational Medicine, Sahlgrenska University Hospital, Göteborg, Sweden aut NATIONALLICENCE 700 1- Barregård Lars Department of Occupational Medicine, Sahlgrenska University Hospital, Göteborg, Sweden aut NATIONALLICENCE 773 0- Biometals Kluwer Academic Publishers 10/4(1997-12-01), 357-361 0966-0844 10:4<357 1997 10 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer