caa a22 4500 477132588 CHVBK 20180405111707.0 cr unu---uuuuu 170330e19971201xx s 000 0 eng 10.1023/A:1018388803491 doi (NATIONALLICENCE)springer-10.1023/A:1018388803491 Uptake of Ga-67 into rat cerebral hemisphere and cerebellum. Comparison with Fe-59 [Elektronische Daten] [Aleksandar Radunovic, Mark Habgood, Michael Bradbury] Transferrin and transferrin receptors play an important role in the transport of iron into the brain. To determine whether gallium enters the brain by the same mechanism, uptakes of Ga and 59Fe have been compared under controlled conditions. Rates of gallium penetration into brain (K) were four times slower than those for 59Fe. Kin for Ga when infused with citrate were 0.88 ± 0.24 and 0.94 ± 0.39 x 10 ml gh for cerebral hemisphere and cerebellum, respectively. When infused as the transferrin complex, Ga uptake into the brain was not different from that when infused with citrate. The presence of the anti-transferrin receptor antibody OX-26 significantly reduced uptake of Fe by 60% and 64% into cerebral hemisphere and cerebellum, respectively. By contrast, pretreatment of rats with OX-26 enhanced the uptake of Ga into brain, particularly when infused with citrate; mean increases in uptake of Ga were 120% and 144% for cerebral hemisphere and cerebellum, respectively. Purified Ga-transferrin was also taken up into both brain regions examined in the presence of OX-26. These results indicate that the transport of non-transferrin bound gallium is an important mechanism for gallium uptake into brain. Chapman and Hall, 1997 blood-brain barrier nationallicence gallium nationallicence iron nationallicence transferrin nationallicence transferrin receptor nationallicence Radunovic Aleksandar Physiology Group, King's College London, London, UK aut Habgood Mark Physiology Group, King's College London, London, UK aut Bradbury Michael Physiology Group, King's College London, London, UK aut Biometals Kluwer Academic Publishers 10/4(1997-12-01), 343-349 0966-0844 10:4<343 1997 10 10534 https://doi.org/10.1023/A:1018388803491 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018388803491 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Radunovic Aleksandar Physiology Group, King's College London, London, UK aut NATIONALLICENCE 700 1- Habgood Mark Physiology Group, King's College London, London, UK aut NATIONALLICENCE 700 1- Bradbury Michael Physiology Group, King's College London, London, UK aut NATIONALLICENCE 773 0- Biometals Kluwer Academic Publishers 10/4(1997-12-01), 343-349 0966-0844 10:4<343 1997 10 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer