caa a22 4500 47713260X CHVBK 20180405111708.0 cr unu---uuuuu 170330e19971201xx s 000 0 eng 10.1023/A:1018332618512 doi (NATIONALLICENCE)springer-10.1023/A:1018332618512 The protective effect of zinc sulphate pretreatment against duodenal ulcers in the rat [Elektronische Daten] [B. Troskot, V.N. Simicevic, M. Dodig, I. Rotkvic, D. Ivankovic, M. Duvnjak] Exogenously administered zinc compounds have been shown to possess antiulcer activity in the development of gastric lesions. The aim of this study was to investigate the effects of zinc sulphate pretreatment of rats on cysteamine-induced duodenal ulcers and to correlate them with changes in zinc serum and tissue levels. Atomic absorption spectrophotometry was used to determine zinc serum and tissue concentrations in all animal groups. Cysteamine produced marked duodenal ulceration in control animals 24 h after application, with an increase in endogenous zinc tissue concentrations and a marked decrease in serum concentrations. Zinc sulphate (20, 40 or 80 mg kg-1) applied per os one hour prior to cysteamine application inhibited the development of duodenal lesions in a dose-related manner. The application of zinc sulphate in a single intraperitoneal (i.p.) application (80 mg kg-1) did not, however, prevent the formation of duodenal lesions. In order to assess zinc absorption from the gastrointestinal tract, one group of rats received a single oral dose of zinc sulphate (80 mg kg) without cysteamine application. The observations of this study seem to indicate that zinc plays an important cytoprotective role in duodenal ulcer disease. Chapman and Hall, 1997 cysteamine nationallicence cytoprotection nationallicence duodenal ulcer nationallicence rat nationallicence zinc nationallicence Troskot B. Department of Gastroenterology, Clinical Hospital ‘Sestre Milosrdnice', Medical School, University of Zagreb, Zagreb, Croatia aut Simicevic V.N. Biomedical Department, PLIVA Pharmaceutical Company, Research Institute, Zagreb, Croatia aut Dodig M. Department of Gastroenterology, Clinical Hospital ‘Sestre Milosrdnice', Medical School, University of Zagreb, Zagreb, Croatia aut Rotkvic I. Department of Gastroenterology, Clinical Hospital ‘Sestre Milosrdnice', Medical School, University of Zagreb, Zagreb, Croatia aut Ivankovic D. Department of Statistics, Epidemiology and Informatics, School of Public Health Andrija Stampar, Medical School, University of Zagreb, Zagreb, Croatia aut Duvnjak M. Department of Gastroenterology, Clinical Hospital ‘Sestre Milosrdnice', Medical School, University of Zagreb, Zagreb, Croatia aut Biometals Kluwer Academic Publishers 10/4(1997-12-01), 325-329 0966-0844 10:4<325 1997 10 10534 https://doi.org/10.1023/A:1018332618512 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018332618512 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Troskot B. Department of Gastroenterology, Clinical Hospital ‘Sestre Milosrdnice', Medical School, University of Zagreb, Zagreb, Croatia aut NATIONALLICENCE 700 1- Simicevic V.N. Biomedical Department, PLIVA Pharmaceutical Company, Research Institute, Zagreb, Croatia aut NATIONALLICENCE 700 1- Dodig M. Department of Gastroenterology, Clinical Hospital ‘Sestre Milosrdnice', Medical School, University of Zagreb, Zagreb, Croatia aut NATIONALLICENCE 700 1- Rotkvic I. Department of Gastroenterology, Clinical Hospital ‘Sestre Milosrdnice', Medical School, University of Zagreb, Zagreb, Croatia aut NATIONALLICENCE 700 1- Ivankovic D. Department of Statistics, Epidemiology and Informatics, School of Public Health Andrija Stampar, Medical School, University of Zagreb, Zagreb, Croatia aut NATIONALLICENCE 700 1- Duvnjak M. Department of Gastroenterology, Clinical Hospital ‘Sestre Milosrdnice', Medical School, University of Zagreb, Zagreb, Croatia aut NATIONALLICENCE 773 0- Biometals Kluwer Academic Publishers 10/4(1997-12-01), 325-329 0966-0844 10:4<325 1997 10 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer