caa a22 4500 477136206 CHVBK 20180405111718.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1023/A:1018376516116 doi (NATIONALLICENCE)springer-10.1023/A:1018376516116 Side-chain conformation and dynamics in a solid peptide: CP-MAS NMR study of valine rotamers and methyl-group relaxation in fully 13C-labelled antamanide [Elektronische Daten] [Suzana Straus, Tobias Bremi, Richard Ernst] The effect of the crystal lattice on the side-chain conformation andside-chain dynamics in peptides is investigated by solid-state NMR, using thecyclic decapeptide antamanide as an example. The study takes advantage of the13C assignment of the backbone and side chains based on theresolution-enhanced 2D spin-diffusion spectra by heteronuclear and homonucleardecoupling. The spectra even allow for a stereospecific assignment of theγ-carbons of the valine residue. It is found that the valine side chaincoexists in two static rotamer conformations which have not been observed byX-ray crystallography. In addition, remarkable effects of the crystal packingon the methyl-group rotation frequency are found from 13Crelaxation measurements. Kluwer Academic Publishers, 1997 Solid-state NMR nationallicence Peptide dynamics nationallicence Side-chain conformation nationallicence Methyl-group relaxation nationallicence Homonuclear decoupling nationallicence Stereospecific assignment nationallicence Straus Suzana Laboratorium für Physikalische Chemie, ETH Zentrum, CH-8092, Zürich, Switzerland aut Bremi Tobias Laboratorium für Physikalische Chemie, ETH Zentrum, CH-8092, Zürich, Switzerland aut Ernst Richard Laboratorium für Physikalische Chemie, ETH Zentrum, CH-8092, Zürich, Switzerland aut Journal of Biomolecular NMR Kluwer Academic Publishers 10/2(1997-09-01), 119-128 0925-2738 10:2<119 1997 10 10858 https://doi.org/10.1023/A:1018376516116 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018376516116 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Straus Suzana Laboratorium für Physikalische Chemie, ETH Zentrum, CH-8092, Zürich, Switzerland aut NATIONALLICENCE 700 1- Bremi Tobias Laboratorium für Physikalische Chemie, ETH Zentrum, CH-8092, Zürich, Switzerland aut NATIONALLICENCE 700 1- Ernst Richard Laboratorium für Physikalische Chemie, ETH Zentrum, CH-8092, Zürich, Switzerland aut NATIONALLICENCE 773 0- Journal of Biomolecular NMR Kluwer Academic Publishers 10/2(1997-09-01), 119-128 0925-2738 10:2<119 1997 10 10858 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer